Multiple Roles for B-Lymphocytes in Sjogren's Syndrome

被引：23

作者：

Ambrus, Julian Lawrence, Jr. ^{[1
]}

Suresh, Lakshmanan ^{[2
,3
]}

Peck, Ammon ^{[4
]}

机构：

[1] SUNY Buffalo, Div Allergy Immunol & Rheumatol, Sch Med, 100 High St, Buffalo, NY 14203 USA

[2] SUNY Buffalo, Immco Diagnost, Sch Dent Sci, Buffalo, NY 14203 USA

[3] SUNY Buffalo, Dept Oral Diagnost Sci, Sch Dent Sci, Buffalo, NY 14203 USA

[4] Univ Florida, Coll Vet Med, Gainesville, FL 32608 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 10期

关键词：

Sjogren's syndrome; B cells; marginal zone B cells; BAFF TRANSGENIC MICE; NON-HODGKIN-LYMPHOMA; SALIVARY-GLANDS; I INTERFERON; CLASSIFICATION CRITERIA; IMMUNE-RESPONSES; C57BL/6.NOD-AEC1AEC2; MICE; RITUXIMAB TREATMENT; CELL SUBSETS; B10; CELLS;

D O I：

10.3390/jcm5100087

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sjogren's syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell-directed therapies in the management of patients with SS.

引用

页数：10

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