On the Curcumin and β-Cyclodextrin Interaction in Aqueous Media. Spectrophotometric and Electrochemical Study

被引:10
作者
Martinez-Guerra, Jorge [1 ]
Palomar-Pardave, Manuel [2 ]
Romero-Romo, Mario [2 ]
Corona-Avendano, Silvia [2 ]
Guzman-Hernandez, Dafne-Sarahia [3 ]
Rojas-Hernandez, Alberto [1 ]
Teresa Ramirez-Silva, Maria [1 ]
机构
[1] Univ Autonoma Metropolitana Iztapalapa, Quim, Av San Rafael Atlixco 186, Col Vicentina 09340, Cdmx, Mexico
[2] Univ Autonoma Metropolitana Azcapotzalco, Mat, Av San Pablo 180, Col Reynosa Tamaulipas 02200, Cdmx, Mexico
[3] Univ Autonoma Metropolitana Iztapalapa, CONACYT, Quim, Av San Rafael Atlixco 186, Col Vicentina 09340, Cdmx, Mexico
关键词
Curcumin; beta-Cyclodextrin; Inclusion complex; Quantification; Stability; Spectrophotometry; CARBON-PASTE ELECTRODES; VOLTAMMETRIC DETERMINATION; QUANTIFICATION; INCLUSION; CONSTANTS; OXIDATION; DIAGRAMS; BEHAVIOR; BINDER;
D O I
10.1002/celc.202101534
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
It is shown from UV/Vis spectrophotometry measurements, that up to two inclusion complexes between curcumin and beta-cyclodextrin, namely H(3)Cur(beta-CD) and H(2)Cur(beta-CD)(2), can be formed in aqueous solution at pH-3.6, where the fully protonated and neutral species of curcumin, H(3)Cur, predominate depending on the beta-CD concentration. The thermodynamic formation constants of these supramolecular complexes were determined and the molar absorptivity coefficients of H(3)Cur, H(3)Cur(beta-CD) and H(3)Cur(beta-CD)(2), species were assessed. In the absence of beta-CD curcumin degradation increases linearly with time at a rate of 3.25%min(-1). However, in its presence, the rate drastically diminishes to 0.11 % min(-1). These results were corroborated from independent electrochemical measurements using a bare carbon paste electrode. At 0.01 M beta-CD the first voltammogram cycle displayed single anodic and cathodic peaks while the second cycle is formed by two anodic peaks and one cathodic, all of them being due to single-electron adsorption-controlled processes. The current of these peaks can be used to quantify curcumin concentration in real samples.
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页数:9
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