Quantitative structure-activity relationships of some HIV-protease inhibitors

被引：15

作者：

Gupta, SP ^{[1
]}

Babu, MS ^{[1
]}

Kaw, N ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Pilani 333031, Rajasthan, India

来源：

JOURNAL OF ENZYME INHIBITION | 1999年 / 14卷 / 02期

关键词：

quantitative structure-activity relationship; HIV-1 protease inhibitors; cycloalkylpyranones;

D O I：

10.3109/14756369909036549

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A quantitative structure-activity relationship (QSAR) study has been made on different series of cycloalkylpyranones acting as human-immunodeficiency-virus type 1 (HIV-1) protease inhibitors. The results suggest that the enzyme binding affinity of the: compounds would be favoured by a cyclooctyl ring, a 3-cyclopropylphenylmethyl substituent at the pyranone ring, and a 4-CN-2-pyridine-, an N-Me-imidazole-, or a 3- or 4-CN-phenyl-sulfonamide group at the meta position of the phenyl ring of the 3-substituent.

引用

页码：109 / 123

页数：15

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