The artificial ovary: current status and future perspectives

被引：101

作者：

Amorim, Christiani A. ^{[1
]}

Shikanov, Ariella ^{[2
]}

机构：

[1] Catholic Univ Louvain, Inst Rech Expt & Clin, Pole Rech Gynecol, Ave Mounier 52,Bte B1-52-02, B-1200 Brussels, Belgium

[2] Univ Michigan, Dept Macromol Sci & Engn, 1101 Beal Ave,Room 2126 LBME, Ann Arbor, MI 48109 USA

来源：

FUTURE ONCOLOGY | 2016年 / 12卷 / 20期

关键词：

artificial ovary; biomaterials; cancer patients; fertility preservation; in vitro culture; preantral follicles; transplantation; PLURIPOTENT STEM-CELLS; TISSUE-ENGINEERING APPLICATIONS; HUMAN ISLET TRANSPLANTATION; ISOLATED MURINE FOLLICLES; FERTILITY PRESERVATION; EXTRACELLULAR-MATRIX; PREANTRAL FOLLICLES; CANCER SURVIVORS; ANTRAL FOLLICLES; FIBRIN SCAFFOLD;

D O I：

10.2217/fon-2016-0202

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cryopreservation and transplantation of ovarian tissue has proved to be a promising technique to safeguard fertility in cancer patients. However, with some types of cancer, there is a risk of transmitting malignant cells present in the cryopreserved tissue, so transplantation after disease remission is not advisable. To restore fertility in these patients, some research teams have been developing a transplantable artificial ovary, whose main goal is to mimic the natural organ. It should be composed of a matrix that encapsulates and protects follicles, as well as ovarian cells, which are necessary for follicle survival and development. This article reviews progress made in the creation of a transplantable artificial ovary and discusses future trends for its development.

引用

页码：2323 / 2332

页数：10

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