Ring-Opening Diarylation of Siloxydifluorocyclopropanes by Ag(I) Catalysis: Stereoselective Construction of 2-Fluoroallylic Scaffold

被引：33

作者：

Song, Xiaoning ^{[1
]}

Xu, Cong ^{[1
]}

Du, Dongxu ^{[1
]}

Zhao, Ziming ^{[1
]}

Zhu, Dongsheng ^{[1
]}

Wang, Mang ^{[1
,2
]}

机构：

[1] Northeast Normal Univ, Fac Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Jilin, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 24期

关键词：

GEM-DIFLUOROCYCLOPROPANES; CARBONYL-COMPOUNDS; DOMINO REACTION; DERIVATIVES; FLUOROALKENES; REDUCTION; 3,3-DIFLUOROPROPENES; MONOFLUOROALKENES; DIFLUOROCARBENE; DEFLUORINATION;

D O I：

10.1021/acs.orglett.7b03254

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A silver-catalyzed, defluorination ring-opening diarylation of siloxy 2,2-difluorocyclOpropanes, with two arenes, to directly prepare polysubstituted 2-fluoroallylic compounds, is described. This multicomponent reaction proceeds smoothly in good stereoselectivity, which is due to a chelation-Controlled addition of arenes to a fluorinated ketone intermediate.

引用

页码：6542 / 6545

页数：4

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