Perineural invasion and associated pain in pancreatic cancer

被引：354
作者：
Bapat, Aditi A. [1 ]
Hostetter, Galen [2 ]
Von Hoff, Daniel D. [1 ]
Han, Haiyong [1 ]
机构：
[1] Translat Genom Res Inst, Clin Translat Res Div, Scottsdale, AZ 85259 USA
[2] Translat Genom Res Inst, Integrated Canc Genom Div, Phoenix, AZ 85004 USA
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 10期
基金：
美国国家卫生研究院;
关键词：
NERVE GROWTH-FACTOR; MYELIN-ASSOCIATED GLYCOPROTEIN; CELL-ADHESION MOLECULE; FACTOR FAMILY-MEMBERS; CELIAC PLEXUS BLOCK; DORSAL-ROOT GANGLIA; IN-VITRO; DUCTAL ADENOCARCINOMA; PROGNOSTIC-FACTOR; TRPV1; EXPRESSION;
D O I：
10.1038/nrc3131
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer. PNI is a process whereby cancer cells invade the surrounding nerves, thus providing an alternative route for metastatic spread and pain generation. PNI is thought to be an indicator of aggressive tumour behaviour and has been shown to correlate with poor prognosis of patients with pancreatic cancer. Recent studies demonstrated that some signalling molecules and pathways that are involved in PNI are also involved in pain generation. Targeting these signalling pathways has shown some promise in alleviating pain and reducing PNI, which could potentially improve treatment outcomes for patients with pancreatic cancer.
引用
收藏
页码：695 / 707
页数：13
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