Comparison of the anti-obesity and hypocholesterolaemic effects of single Lactobacillus casei strain Shirota and probiotic cocktail

被引：12

作者：

Aazmi, Shafiq ^{[1
,2
]}

Teh, Lay Kek ^{[1
,2
]}

Ramasamy, Kalavathy ^{[2
,3
]}

Rahman, Thuhairah ^{[4
]}

Salleh, Mohd Zaki ^{[1
,2
]}

机构：

[1] Univ Teknol MARA, Integrat Pharmacogen Inst iPROMISE, Puncak Alam 42300, Malaysia

[2] Univ Teknol MARA, Fac Pharm, Puncak Alam 42300, Malaysia

[3] Univ Teknol MARA, Fac Pharm, Collaborat Drug Discovery Res CDDR Grp, Brain & Neurosci Communities Res, Puncak Alam 42300, Malaysia

[4] Univ Teknol MARA, Fac Med, Sungai Buloh 47000, Malaysia

来源：

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY | 2015年 / 50卷 / 07期

关键词：

Anti-obesity; diet-induced obesity; LAB13; LACTO-5(TM); OBESITY; LEPTIN; ADIPONECTIN; PLASMA; BODY;

D O I：

10.1111/ijfs.12810

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study compared the efficacy of Lactobacillus casei strain Shirota (LAB13) and a probiotic cocktail for their anti-obesity and other lipid profile modulating effects. Diet-induced obese rats were supplemented with two different probiotics which are LAB13 (1x10(9) CFUday(-1) per rat) and cocktail of five bacterial strains (1x10(9) CFUday(-1) per rat) for 12weeks. Comparative data on weight gain, energy intake, liver weight, subcutaneous fat, total fat weights, total cholesterol and leptin levels in both treatment groups showed significant reduction in probiotic-treated groups compared to the obese control group. Both probiotics have the anti-obesity and hypocholesterolaemic effects and are able to reduce body weight and fats via reduction in energy intake. Only LAB13 was able to reduce the level of triglyceride significantly. Therefore, the LAB13 is equally effective compared to the probiotic cocktail in weight reduction. LAB13 is more effective in improving lipid profile which is a common medical complication of obesity.

引用

页码：1589 / 1597

页数：9

共 31 条

[1] Leptin [J].

Ahima, RS ;

Flier, JS .

ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437

[2] Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats [J].

An, Hyang Mi ;

Park, Shin Young ;

Lee, Do Kyung ;

Kim, Jung Rae ;

Cha, Min Kyeong ;

Lee, Si Won ;

Lim, Hyung Taeck ;

Kim, Kyung Jae ;

Ha, Nam Joo .

LIPIDS IN HEALTH AND DISEASE, 2011, 10

[3]

[Anonymous], OB OV FACT SHEET

[4]

Aragon George, 2010, Gastroenterol Hepatol (N Y), V6, P39

[5] Decreased Fat Storage by Lactobacillus Paracasei Is Associated with Increased Levels of Angiopoietin-Like 4 Protein (ANGPTL4) [J].

Aronsson, Linda ;

Huang, Ying ;

Parini, Paolo ;

Korach-Andre, Marion ;

Hakansson, Janet ;

Gustafsson, Jan-Ake ;

Pettersson, Sven ;

Arulampalam, Velmurugesan ;

Rafter, Joseph .

PLOS ONE, 2010, 5 (09) :1-7

[6] Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance [J].

Caro, JF ;

Kolaczynski, JW ;

Nyce, MR ;

Ohannesian, JP ;

Opentanova, I ;

Goldman, WH ;

Lynn, RB ;

Zhang, PL ;

Sinha, MK ;

Considine, RV .

LANCET, 1996, 348 (9021) :159-161

[7] Antagonistic activity of Lactobacillus casei strain Shirota against gastrointestinal Listeria monocytogenes infection in rats [J].

de Waard, R ;

Garssen, J ;

Bokken, GCAM ;

Vos, JG .

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2002, 73 (01) :93-100

[8] The role of the novel adipocyte-derived hormone adiponectin in human disease [J].

Díez, JJ ;

Iglesias, P .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 (03) :293-300

[9]

FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499

[10] Leptin and the regulation of body weight in mammals [J].

Friedman, JM ;

Halaas, JL .

NATURE, 1998, 395 (6704) :763-770

← 1 2 3 4 →