The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease

被引：34

作者：

Mowry, Ellen M. ^{[1
]}

Glenn, Justin D. ^{[2
]}

机构：

[1] Johns Hopkins Sch Med, Dept Neurol, 600 North Wolfe St,Pathol 627, Baltimore, MD 21287 USA

[2] Johns Hopkins Sch Med, Dept Neurol, 600 North Wolfe St,Meyer Bldg,Room 6-138, Baltimore, MD 21287 USA

来源：

NEUROLOGIC CLINICS | 2018年 / 36卷 / 01期

关键词：

Gut microbiome; Multiple sclerosis; Neuroinflarnmation; Gut bacteria; Experimental autoimmune encephalomyelitis; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NERVOUS-SYSTEM AUTOIMMUNITY; DOUBLE-BLIND; VITAMIN-D; T-CELLS; SUPPLEMENTATION; RISK; IMPACT; DIET; MECHANISMS;

D O I：

10.1016/j.ncl.2017.08.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease of unknown etiology, although genetic components and environmental triggers are thought to collude to commence pathogenesis. Numerous investigations are now demonstrating the role of the gut microbiota in neuroinflammation and how alterations in its content may be associated with MS disease. This article explores the studies using MS rodent models to determine the roles of gut bacteria in neuroinflammatory disease, evaluate the evidence linking gut bacterial dysbiosis and MS, and give insight into potential MS therapies targeting the gut microbiota currently under investigation.

引用

页码：185 / +

页数：13

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