bioabsorbable;
nitrided iron stent;
cytotoxicity;
size effect;
test methodology;
IN-VITRO CORROSION;
PURE IRON;
INTRAVASCULAR ULTRASOUND;
BIOCOMPATIBILITY;
IMPLANTATION;
DEGRADATION;
BIOMATERIAL;
RESISTANCE;
TITANIUM;
BEHAVIOR;
D O I:
10.1002/jbm.b.33246
中图分类号:
R318 [生物医学工程];
学科分类号:
0831 ;
摘要:
Comprehensive assessments of the cytotoxicity of nitrided iron, a promising bioabsorbable metallic material, were conducted using in vitro methods. Extracting and standing experiments were conducted to determine the factors influencing the precipitation of the extract during extraction and incubation. The MTT method, fluorescent staining, and direct contact method were used to explore the in vitro cytotoxicity of nitrided iron stent extracts, nitrided iron foils, and their bulk corrosion products. The extracting and standing experiments confirmed that the extraction medium and available oxygen are crucial for precipitation during the extraction and incubation processes. In the MTT test, the extract of nitrided iron stents with a high iron ion concentration (124.11 +/- 7.55 g/mL) was not cytotoxic to L929 fibroblasts. Thus, the in vitro cytotoxicity of nitrided iron stents was actually caused by the size effect of corrosion particles and not the material itself. Test methodology for in vitro cytotoxicity of biodegradable iron-based materials was analyzed, and the results demonstrate that multiple methods should be combined for comprehensive evaluation of the cytocompatibility of bioabsorbable iron-based materials to get an impartial conclusion. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 764-776, 2015.
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
Brown, David A.
;
Lee, Edward W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
Lee, Edward W.
;
Loh, Christopher T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
Loh, Christopher T.
;
Kee, Stephen T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
机构:
Shanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Feng, Qimao
;
Zhang, Deyuan
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Zhang, Deyuan
;
Xin, Chaohua
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Xin, Chaohua
;
Liu, Xiangdong
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h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Liu, Xiangdong
;
Lin, Wenjiao
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Lin, Wenjiao
;
Zhang, Wanqian
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Zhang, Wanqian
;
Chen, Sun
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Med, Childrens Heart Ctr, Xinhua Hosp, Shanghai 200092, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Chen, Sun
;
Sun, Kun
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Med, Childrens Heart Ctr, Xinhua Hosp, Shanghai 200092, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
Brown, David A.
;
Lee, Edward W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
Lee, Edward W.
;
Loh, Christopher T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
Loh, Christopher T.
;
Kee, Stephen T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Med Ctr, Los Angeles, CA 90095 USA
机构:
Shanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Feng, Qimao
;
Zhang, Deyuan
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Zhang, Deyuan
;
Xin, Chaohua
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Xin, Chaohua
;
Liu, Xiangdong
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Liu, Xiangdong
;
Lin, Wenjiao
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Lin, Wenjiao
;
Zhang, Wanqian
论文数: 0引用数: 0
h-index: 0
机构:
Lifetech Sci Shenzhen Co Ltd, R&D Ctr, Shenzhen 518057, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Zhang, Wanqian
;
Chen, Sun
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Med, Childrens Heart Ctr, Xinhua Hosp, Shanghai 200092, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
Chen, Sun
;
Sun, Kun
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Med, Childrens Heart Ctr, Xinhua Hosp, Shanghai 200092, Peoples R ChinaShanghai Univ Tradit Chinese Med, Dept Cardiol, Shanghai Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China