Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study

被引：2

作者：

Tejera-Vaquerizo, Antonio ^{[1
,2
]}

Boada, Aram ^{[3
]}

Ribero, Simone ^{[4
]}

Puig, Susana ^{[5
,6
]}

Paradela, Sabela ^{[7
]}

Moreno-Ramirez, David ^{[8
]}

Canueto, Javier ^{[9
]}

de Unamuno-Bustos, Blanca ^{[10
]}

Brinca, Ana ^{[11
]}

Descalzo-Gallego, Miguel A. ^{[12
]}

Osella-Abate, Simona ^{[13
]}

Cassoni, Paola ^{[13
]}

Podlipnik, Sebastian ^{[5
,6
]}

Carrera, Cristina ^{[5
,6
]}

Vidal-Sicart, Sergi ^{[14
]}

Pigem, Ramon ^{[5
,6
,15
]}

Toll, Agusti ^{[5
,6
]}

Rull, Ramon

Alos, Llucia ^{[16
]}

Requena, Celia ^{[17
]}

Bolumar, Isidro ^{[18
]}

Traves, Victor ^{[19
]}

Pla, Angel ^{[20
]}

Fernandez-Orland, Almudena ^{[8
]}

Jaka, Ane ^{[3
]}

Fernandez-Figueras, Maria Teresa ^{[21
]}

Richarz, Nina Anika

Vieira, Ricardo ^{[11
]}

Botella-Estrada, Rafael ^{[10
]}

Roman-Curto, Concepcion ^{[9
,22
]}

Ferrandiz-Pulido, Lara ^{[8
]}

Iglesias-Pena, Nicolas ^{[7
]}

Ferrandiz, Carlos ^{[3
]}

Malvehy, Josep ^{[5
,6
]}

Quaglino, Pietro ^{[4
]}

Nagore, Eduardo ^{[17
]}

机构：

[1] Inst Dermatol GlobalDerm, Dermatol Dept, Palma Del Rio 14700, Spain

[2] Hosp San Juan Dios, Cutaneous Oncol Unit, Cordoba 14012, Spain

[3] Univ Autonoma Barcelona, Inst Invest Germans Trias & Pujol, Hosp Univ Germans Trials & Pujol, Dermatol Dept, Badalona 08916, Spain

[4] Univ Turin, Sect Dermatol, Med Sci Dept, I-10124 Turin, Italy

[5] Univ Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Hosp Clin, Melanoma Unit,Dermatol Dept, Barcelona 08036, Spain

[6] ISCIII, Biomed Res Networking Ctr Rare Dis CIBERER, Barcelona 28029, Spain

[7] Hosp Univ Coruna, Dept Dermatol, La Coruna 15006, Spain

[8] Hosp Univ Virgen Macarena, Med & Surg Dermatol Dept, Melanoma Unit, Seville 41009, Spain

[9] Complejo Asistencial Univ Salamanca, Dermatol Dept, Salamanca 37007, Spain

[10] Hosp Univ La Fe, Dermatol Dept, Valencia 46126, Spain

[11] Univ Hosp Coimbra, Dept Dermatol, P-3000075 Coimbra, Portugal

[12] Acad Espanola Dermatol, Fdn Piel Sana, Unidad Invest, Madrid 28008, Spain

[13] Univ Turin, Sect Surg Pathol, Med Sci Dept, I-10124 Turin, Italy

[14] Univ Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Hosp Clin Barcelona, Nucl Med Dept, Barcelona 08036, Spain

[15] Univ Barcelona, Hosp Clin, Surg Dept, Barcelona 08036, Spain

[16] Univ Barcelona, Hosp Clin, Pathol Dept, Barcelona 08036, Spain

[17] Inst Valenciano Oncol, Dermatol Dept, Valencia 46009, Spain

[18] Inst Valenciano Oncol, Surg Dept, Valencia 46009, Spain

[19] Inst Valenciano Oncol, Pathol Dept, Valencia 46009, Spain

[20] Inst Valenciano Oncol, Otorhinolaringol Dept, Valencia 46009, Spain

[21] Hosp Univ Germans Trial & Pujol, Pathol Dept, Badalona 08916, Spain

[22] Complejo Asistencial Univ Salamanca, Inst Invest Biomed Salamanca, Salamanca 37007, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 24期

关键词：

melanoma; sentinel lymph node biopsy; survival; PRIMARY CUTANEOUS MELANOMA; SPANISH ACADEMY; POSITIVITY; ASSOCIATION; DERMATOLOGY; PROGRESSION; METASTASIS; PREDICTORS; REGRESSION; STATEMENT;

D O I：

10.3390/jcm10245878

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (<= 1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (p < 0.001) and 97.3% vs. 68.7% (p < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients.

引用

页数：14

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