Exploring the Genomes of Cancer Cells: Progress and Promise

被引：485

作者：

Stratton, Michael R. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

来源：

SCIENCE | 2011年 / 331卷 / 6024期

基金：

英国惠康基金;

关键词：

KINASE GENE FAMILY; SOMATIC MUTATIONS; HUMAN BREAST; LUNG-CANCER; POLYCYTHEMIA-VERA; FREQUENT MUTATION; INHIBITION; PATTERNS; EVOLUTION; REARRANGEMENT;

D O I：

10.1126/science.1204040

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The description and interpretation of genomic abnormalities in cancer cells have been at the heart of cancer research for more than a century. With exhaustive sequencing of cancer genomes across a wide range of human tumors well under way, we are now entering the end game of this mission. In the forthcoming decade, essentially complete catalogs of somatic mutations will be generated for tens of thousands of human cancers. Here, I provide an overview of what these efforts have revealed to date about the origin and behavioral features of cancer cells and how this genomic information is being exploited to improve diagnosis and therapy of the disease.

引用

页码：1553 / 1558

页数：6

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