Sex differences in the vaccine-specific and non-targeted effects of vaccines

被引：45

作者：

Flanagan, Katie L. ^{[1
]}

Klein, Sabra L. ^{[2
]}

Skakkebaek, Niels E. ^{[3
]}

Marriott, Ian ^{[4
]}

Marchant, Arnaud ^{[5
]}

Selin, Liisa ^{[6
]}

Fish, Eleanor N. ^{[7
,8
]}

Prentice, Andrew M. ^{[9
,10
]}

Whittle, Hilton ^{[1
]}

Benn, Christine Stabell ^{[11
,12
]}

Aaby, Peter ^{[11
,12
]}

机构：

[1] MRC Labs, Fajara, Gambia

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

[3] Rigshosp, Dept Growth & Reprod, DK-2100 Copenhagen, Denmark

[4] Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA

[5] Univ Libre Bruxelles, Inst Med Immunol, Brussels, Belgium

[6] Univ Massachusetts, Sch Med, Worcester, MA USA

[7] Univ Toronto, Univ Hlth Network, Toronto, ON, Canada

[8] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[9] London Sch Hyg & Trop Med, MRC Int Nutr Grp, London WC1, England

[10] London Sch Hyg & Trop Med, MRC Int Nutr Grp, Keneba, Gambia

[11] State Serum Inst, Bandim Hlth Project, DK-2300 Copenhagen, Denmark

[12] Indepth Network, Bandim Hlth Project, Bissau Codex 1004, Guinea Bissau

来源：

VACCINE | 2011年 / 29卷 / 13期

关键词：

Vaccines; Non-specific effects; Non-targeted effects; Sex differences; Innate immunity; Adaptive immunity; Sex hormones; X-linked genes; Vitamin A; Reactogenicity; Heterologous immunity; FEMALE-MALE MORTALITY; DIPHTHERIA-TETANUS-PERTUSSIS; TITER MEASLES-VACCINE; GUINEA-BISSAU; ROUTINE VACCINATIONS; INNATE IMMUNITY; HETEROLOGOUS IMMUNITY; CHILDHOOD MORTALITY; CYTOKINE PRODUCTION; GUERIN VACCINATION;

D O I：

10.1016/j.vaccine.2011.01.071

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccines have non-specific effects (NSE) on subsequent morbidity and mortality from non-vaccine related infectious diseases. Thus NSE refers to any effect that cannot be accounted for by the induction of immunity against the vaccine-targeted disease. These effects are sex-differential, generally being more pronounced in females than males. Furthermore, the NSE are substantial causing greater than fifty percent changes in all cause mortality in certain settings, yet have never been systematically tested despite the fact that millions of children receive vaccines each year. As we strive to eliminate infectious diseases through vaccination programmes, the relative impact of NSE of vaccines on mortality is likely to increase, raising important questions regarding the future of certain vaccine schedules. A diverse group of scientists met in Copenhagen to discuss non-specific and sex-differential effects of vaccination, and explore plausible biological explanations. Herein we describe the contents of the meeting and the establishment of the 'Optimmunize' network aimed at raising awareness of this important issue among the wider scientific community.

引用

页码：2349 / 2354

页数：6

共 63 条

[1] The sequence of vaccinations and increased female mortality after high-titre measles vaccine: Trials from rural Sudan and Kinshasa [J].