Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

被引：81

作者：

Anderson, Carl A. ^{[1
]}

Soranzo, Nicole ^{[1
]}

Zeggini, Eleftheria ^{[1
]}

Barrett, Jeffrey C. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1HH, Cambs, England

来源：

PLOS BIOLOGY | 2011年 / 9卷 / 01期

基金：

英国惠康基金;

关键词：

INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; SUSCEPTIBILITY LOCI; VARIANTS; LINKAGE; FAMILIES; GENETICS; IDENTIFICATION; CHROMOSOME-16; AUTOPHAGY;

D O I：

10.1371/journal.pbio.1000580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页数：5

共 32 条

[21] Human genetics illuminates the paths to metabolic disease [J].

O'Rahilly, Stephen .

NATURE, 2009, 462 (7271) :307-314

[22] Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility [J].

Parkes, Miles ;

Barrett, Jeffrey C. ;

Prescott, Natalie J. ;

Tremelling, Mark ;

Anderson, Carl A. ;

Fisher, Sheila A. ;

Roberts, Roland G. ;

Nimmo, Elaine R. ;

Cummings, Fraser R. ;

Soars, Dianne ;

Drummond, Hazel ;

Lees, Charlie W. ;

Khawaja, Saud A. ;

Bagnall, Richard ;

Burke, Denis A. ;

Todhunter, Catherine E. ;

Ahmad, Tariq ;

Onnie, Clive M. ;

McArdle, Wendy ;

Strachan, David ;

Bethel, Graeme ;

Bryan, Claire ;

Lewis, Cathryn M. ;

Deloukas, Panos ;

Forbes, Alastair ;

Sanderson, Jeremy ;

Jewell, Derek P. ;

Satsangi, Jack ;

Mansfield, John C. ;

Cardon, Lon ;

Mathew, Christopher G. .

NATURE GENETICS, 2007, 39 (07) :830-832

[23]

Pugazhendhi Srinivasan, 2008, Indian J Gastroenterol, V27, P201

[24] Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions [J].

Raychaudhuri, Soumya ;

Plenge, Robert M. ;

Rossin, Elizabeth J. ;

Ng, Aylwin C. Y. ;

Purcell, Shaun M. ;

Sklar, Pamela ;

Scolnick, Edward M. ;

Xavier, Ramnik J. ;

Altshuler, David ;

Daly, Mark J. .

PLOS GENETICS, 2009, 5 (06)

[25] Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis [J].

Rioux, John D. ;

Xavier, Ramnik J. ;

Taylor, Kent D. ;

Silverberg, Mark S. ;

Goyette, Philippe ;

Huett, Alan ;

Green, Todd ;

Kuballa, Petric ;

Barmada, M. Michael ;

Datta, Lisa Wu ;

Shugart, Yin Yao ;

Griffiths, Anne M. ;

Targan, Stephan R. ;

Ippoliti, Andrew F. ;

Bernard, Edmond-Jean ;

Mei, Ling ;

Nicolae, Dan L. ;

Regueiro, Miguel ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Rotter, Jerome I. ;

Duerr, Richard H. ;

Cho, Judy H. ;

Daly, Mark J. ;

Brant, Steven R. .

NATURE GENETICS, 2007, 39 (05) :596-604

[26] The future of genetic studies of complex human diseases [J].

Risch, N ;

Merikangas, K .

SCIENCE, 1996, 273 (5281) :1516-1517

[27] Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore [J].

Tan, Jonathan T. ;

Ng, Daniel P. K. ;

Nurbaya, Siti ;

Ye, Sandra ;

Lim, Xiu Li ;

Leong, Helen ;

Seet, Lin Tze ;

Siew, Wei Fong ;

Kon, Winston ;

Wong, Tien Yin ;

Saw, Seang Mei ;

Aung, Tin ;

Chia, Kee Seng ;

Lee, Jeannette ;

Chew, Suok Kai ;

Seielstad, Mark ;

Tai, E. Shyong .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (01) :390-397

[28] Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis [J].

Voight, Benjamin F. ;

Scott, Laura J. ;

Steinthorsdottir, Valgerdur ;

Morris, Andrew P. ;

Dina, Christian ;

Welch, Ryan P. ;

Zeggini, Eleftheria ;

Huth, Cornelia ;

Aulchenko, Yurii S. ;

Thorleifsson, Gudmar ;

McCulloch, Laura J. ;

Ferreira, Teresa ;

Grallert, Harald ;

Amin, Najaf ;

Wu, Guanming ;

Willer, Cristen J. ;

Raychaudhuri, Soumya ;

McCarroll, Steve A. ;

Langenberg, Claudia ;

Hofmann, Oliver M. ;

Dupuis, Josee ;

Qi, Lu ;

Segre, Ayellet V. ;

van Hoek, Mandy ;

Navarro, Pau ;

Ardlie, Kristin ;

Balkau, Beverley ;

Benediktsson, Rafn ;

Bennett, Amanda J. ;

Blagieva, Roza ;

Boerwinkle, Eric ;

Bonnycastle, Lori L. ;

Bostrom, Kristina Bengtsson ;

Bravenboer, Bert ;

Bumpstead, Suzannah ;

Burtt, Noisel P. ;

Charpentier, Guillaume ;

Chines, Peter S. ;

Cornelis, Marilyn ;

Couper, David J. ;

Crawford, Gabe ;

Doney, Alex S. F. ;

Elliott, Katherine S. ;

Elliott, Amanda L. ;

Erdos, Michael R. ;

Fox, Caroline S. ;

Franklin, Christopher S. ;

Ganser, Martha ;

Gieger, Christian ;

Grarup, Niels .

NATURE GENETICS, 2010, 42 (07) :579-U155

[29] Interpretation of Association Signals and Identification of Causal Variants from Genome-wide Association Studies [J].

Wang, Kai ;

Dickson, Samuel P. ;

Stolle, Catherine A. ;

Krantz, Ian D. ;

Goldstein, David B. ;

Hakonarson, Hakon .

AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 86 (05) :730-742

[30] Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups [J].

Waters, Kevin M. ;

Stram, Daniel O. ;

Hassanein, Mohamed T. ;

Le Marchand, Loic ;

Wilkens, Lynne R. ;

Maskarinec, Gertraud ;

Monroe, Kristine R. ;

Kolonel, Laurence N. ;

Altshuler, David ;

Henderson, Brian E. ;

Haiman, Christopher A. .

PLOS GENETICS, 2010, 6 (08)

← 1 2 3 4 →