Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

被引：81

作者：

Anderson, Carl A. ^{[1
]}

Soranzo, Nicole ^{[1
]}

Zeggini, Eleftheria ^{[1
]}

Barrett, Jeffrey C. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1HH, Cambs, England

来源：

PLOS BIOLOGY | 2011年 / 9卷 / 01期

基金：

英国惠康基金;

关键词：

INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; SUSCEPTIBILITY LOCI; VARIANTS; LINKAGE; FAMILIES; GENETICS; IDENTIFICATION; CHROMOSOME-16; AUTOPHAGY;

D O I：

10.1371/journal.pbio.1000580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页数：5

共 32 条

[1] Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms [J].

Anderson, Carl A. ;

Pettersson, Fredrik H. ;

Barrett, Jeffrey C. ;

Zhuang, Joanna J. ;

Ragoussis, Jiannis ;

Cardon, Lon R. ;

Morris, Andrew P. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 83 (01) :112-119

[2] Genetic analysis in Italian families with inflammatory bowel disease supports linkage to the IBD1 locus -: A GISC study [J].

Annese, V ;

Latiano, A ;

Bovio, P ;

Forabosco, P ;

Piepoli, A ;

Lombardi, G ;

Andreoli, A ;

Astegiano, M ;

Gionchetti, P ;

Riegler, G ;

Sturniolo, GC ;

Clementi, M ;

Rappaport, E ;

Fortina, P ;

Devoto, M ;

Gasparini, P ;

Andriulli, A .

EUROPEAN JOURNAL OF HUMAN GENETICS, 1999, 7 (05) :567-573

[3]

Barrett J.C., 2009, Nat. Genet

[4] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

[5] Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region [J].

Barrett, Jeffrey C. ;

Lee, James C. ;

Lees, Charles W. ;

Prescott, Natalie J. ;

Anderson, Carl A. ;

Phillips, Anne ;

Wesley, Emma ;

Parnell, Kirstie ;

Zhang, Hu ;

Drummond, Hazel ;

Nimmo, Elaine R. ;

Massey, Dunecan ;

Blaszczyk, Kasia ;

Elliott, Timothy ;

Cotterill, Lynn ;

Dallal, Helen ;

Lobo, Alan J. ;

Mowat, Craig ;

Sanderson, Jeremy D. ;

Jewell, Derek P. ;

Newman, William G. ;

Edwards, Cathryn ;

Ahmad, Tariq ;

Mansfield, John C. ;

Satsangi, Jack ;

Parkes, Miles ;

Mathew, Christopher G. ;

Donnelly, Peter ;

Peltonen, Leena ;

Blackwell, Jenefer M. ;

Bramon, Elvira ;

Brown, Matthew A. ;

Casas, Juan P. ;

Corvin, Aiden ;

Craddock, Nicholas ;

Deloukas, Panos ;

Duncanson, Audrey ;

Jankowski, Janusz ;

Markus, Hugh S. ;

McCarthy, Mark I. ;

Palmer, Colin N. A. ;

Plomin, Robert ;

Rautanen, Anna ;

Sawcer, Stephen J. ;

Samani, Nilesh ;

Trembath, Richard C. ;

Viswanathan, Ananth C. ;

Wood, Nicholas ;

Spencer, Chris C. A. ;

Bellenguez, Celine .

NATURE GENETICS, 2009, 41 (12) :1330-U99

[6] American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12 [J].

Brant, SR ;

Fu, YF ;

Fields, CT ;

Baltazar, R ;

Ravenhill, G ;

Pickles, MR ;

Rohal, PM ;

Mann, J ;

Kirschner, BS ;

Jabs, EW ;

Bayless, TM ;

Hanauer, SB ;

Cho, JH .

GASTROENTEROLOGY, 1998, 115 (05) :1056-1061

[7] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[8] Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1q, 3q, and 4q:: Evidence for epistasis between 1p and IBD1 [J].

Cho, JH ;

Nicolae, DL ;

Gold, LH ;

Fields, CT ;

LaBuda, MC ;

Rohal, PM ;

Pickles, MR ;

Qin, L ;

Fu, YF ;

Mann, JS ;

Kirschner, BS ;

Jabs, EW ;

Weber, J ;

Hanauer, SB ;

Bayless, TM ;

Brant, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7502-7507

[9] Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium [J].

Concannon, Patrick ;

Chen, Wei-Min ;

Julier, Cecile ;

Morahan, Grant ;

Akolkar, Beena ;

Erlich, Henry A. ;

Hilner, Joan E. ;

Nerup, Jorn ;

Nierras, Concepcion ;

Pociot, Flemming ;

Todd, John A. ;

Rich, Stephen S. .

DIABETES, 2009, 58 (04) :1018-1022

[10] Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations [J].

Croucher, PJP ;

Mascheretti, S ;

Hampe, J ;

Huse, K ;

Frenzel, H ;

Stoll, M ;

Lu, T ;

Nikolaus, S ;

Yang, SK ;

Krawczak, M ;

Kim, WH ;

Schreiber, S .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2003, 11 (01) :6-16

← 1 2 3 4 →