TLR agonists as modulators of the innate immune response and their potential as agents against infectious disease

被引：122

作者：

Mifsud, Edin J. ^{[1
]}

Tan, Amabel C. L. ^{[1
]}

Jackson, David C. ^{[1
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷

关键词：

TLR agonists; immunomodulat ion; innate immunity; toll-like receptors; cytokines and inflammation; TOLL-LIKE RECEPTORS; INFLUENZA-A VIRUSES; DOUBLE-STRANDED-RNA; PATTERN-RECOGNITION RECEPTORS; MURINE INTERFERON-GAMMA; CD8(+) T-CELLS; BACTERIAL-DNA; MYCOPLASMA-FERMENTANS; DENDRITIC CELLS; CPG MOTIFS;

D O I：

10.3389/fimmu.2014.00079

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

lmmunotherapies that can either activate or suppress innate immune responses are being investigated as treatments against infectious diseases and the pathology they can cause. The objective of these therapies is to elicit protective immune responses thereby limiting the harm inflicted by the pathogen. The Toll-like receptor (TLR) signaling pathway plays critical roles in numerous host immune defenses and has been identified as an immunotherapeutic target against the consequences of infectious challenge. This review focuses on some of the recent advances being made in the development of TLR-ligands as potential prophylactic and/or therapeutic agents.

引用

页码：1 / 10

页数：10

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