Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

被引：98

作者：

Sul, Ok-Joo ^{[1
,2
]}

Kim, Jin-Chun ^{[3
]}

Kyung, Tae-Wook ^{[1
,2
]}

Kim, Hye-Jin ^{[1
,2
]}

Kim, Youn-Young ^{[1
,2
]}

Kim, Song-Hee ^{[1
,2
]}

Kim, Ji-Soon ^{[3
]}

Choi, Hye-Seon ^{[1
,2
]}

机构：

[1] Univ Ulsan, Program BK21, Dept Biol Sci, Ulsan 680749, South Korea

[2] Univ Ulsan, Immunomodulat Res Ctr, Ulsan 680749, South Korea

[3] Univ Ulsan, Sch Mat Sci & Engn, Ulsan 680749, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2010年 / 74卷 / 11期

关键词：

gold nanoparticles; bone marrow-derived macrophages; nuclear factor (NF)-kappa B; osteoclast formation; antioxidant; BONE; SUPEROXIDE; EXPRESSION; CATALYSIS; WOMEN; NADH;

D O I：

10.1271/bbb.100375

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gold nanoparticles inhibited osteoclast (OC) formation induced by the receptor activator of nuclear factor-kappa B ligand (RANKL) in bone marrow-derived macrophages (BMMs). This was accompanied by a decreased level of tartrate-resistant alkaline phosphatase (TRAP) and less activation of nuclear factor (NF)-kappa B. The nanoparticles also reduced the production of reactive oxygen species (ROS) in response to RANKL and upregulated RANKL-induced glutathione peroxidase-1 (Gpx-1), suggesting a role as an antioxidant in the BMM. The inhibitory effects on OC formation might have been due to elevated defense against oxidative stress.

引用

页码：2209 / 2213

页数：5

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