α-Synuclein and dopamine at the crossroads of Parkinson's disease

被引：230

作者：

Venda, Lara Lourenco ^{[1
]}

Cragg, Stephanie J. ^{[1
]}

Buchman, Vladimir L. ^{[2
]}

Wade-Martins, Richard ^{[1
]}

机构：

[1] Univ Oxford, Oxford Parkinsons Dis Ctr, Oxford OX1 3QX, England

[2] Cardiff Univ, Sch Biosci, Cardiff CF10 3AX, S Glam, Wales

来源：

TRENDS IN NEUROSCIENCES | 2010年 / 33卷 / 12期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; TYROSINE-HYDROXYLASE PHOSPHORYLATION; MITOCHONDRIAL-DNA DELETIONS; SUBSTANTIA-NIGRA; MESSENGER-RNA; MICE LACKING; OXIDATIVE STRESS; GENE-EXPRESSION; RISK-FACTORS; NEURON LOSS;

D O I：

10.1016/j.tins.2010.09.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dopaminergic neurons in the nigrostriatal pathway. Here we ask why these neurons are preferentially susceptible to neurodegeneration in PD and how alpha-synuclein is involved. To address these questions we bring together recent findings from genome-wide association studies, which reveal the involvement of alpha-synuclein gene variants in sporadic PD, with recent studies highlighting important roles for alpha-synuclein in synaptic transmission and dopaminergic neuron physiology. These latest advances add to our understanding of PD etiology and provide a central link between the genetic findings and neurodegeneration observed in sporadic PD.

引用

页码：559 / 568

页数：10

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