Selective detection of hyperpolarized NMR signals derived from para-hydrogen using the Only Para-hydrogen SpectroscopY (OPSY) approach

被引：42

作者：

Aguilar, Juan A. ^{[1
]}

Adams, Ralph W. ^{[1
]}

Duckett, Simon B. ^{[1
]}

Green, Gary G. R. ^{[2
]}

Kandiah, Rathika ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] Bioctr, York Neuroimaging Ctr, York YO10 5DG, N Yorkshire, England

来源：

JOURNAL OF MAGNETIC RESONANCE | 2011年 / 208卷 / 01期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

para-hydrogen; Double quantum (DQ); Zero quantum (ZQ); Multiple quantum; Pulsed field gradients; Coherence order selection; Signal Amplification By Reversible Exchange (SABRE); Solvent suppression; Hyperpolarization; Hydrogenation; DYNAMIC NUCLEAR-POLARIZATION; SITU PHIP-NMR; IN-SITU; HOMOGENEOUS HYDROGENATION; PARAHYDROGEN; ORDER; ACID; C-13; SEPARATION; RHODIUM;

D O I：

10.1016/j.jmr.2010.10.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new family of NMR pulse sequences is reported for the recording of para-hydrogen enhanced NMR spectra. This Only Para-hydrogen Spectroscopy (OPSY) approach uses coherence selection to separate hyperpolarized signals from those of fully relaxed and thermally equilibrated protons. Sequence design, performance, practical aspects and applicability to other hyperpolarization techniques are discussed. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：49 / 57

页数：9

共 47 条

[1] A theoretical basis for spontaneous polarization transfer in non-hydrogenative parahydrogen-induced polarization [J].

Adams, Ralph W. ;

Duckett, Simon B. ;

Green, Richard A. ;

Williamson, David C. ;

Green, Gary G. R. .

JOURNAL OF CHEMICAL PHYSICS, 2009, 131 (19)

[2] Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer [J].

Adams, Ralph W. ;

Aguilar, Juan A. ;

Atkinson, Kevin D. ;

Cowley, Michael J. ;

Elliott, Paul I. P. ;

Duckett, Simon B. ;

Green, Gary G. R. ;

Khazal, Iman G. ;

Lopez-Serrano, Joaqun ;

Williamson, David C. .

SCIENCE, 2009, 323 (5922) :1708-1711

[3] Only para-hydrogen spectroscopy (OPSY), a technique for the selective observation of para-hydrogen enhanced NMR signals [J].

Aguilar, Juan A. ;

Elliott, Paul I. P. ;

Lopez-Serrano, Joaquin ;

Adams, Ralph W. ;

Duckett, Simon B. .

CHEMICAL COMMUNICATIONS, 2007, (11) :1183-1185

[4] SEPARATION OF THE DIFFERENT ORDERS OF NMR MULTIPLE-QUANTUM TRANSITIONS BY THE USE OF PULSED FIELD GRADIENTS [J].

BAX, A ;

DEJONG, PG ;

MEHLKOPF, AF ;

SMIDT, J .

CHEMICAL PHYSICS LETTERS, 1980, 69 (03) :567-570

[5] SEPARATION OF NET POLARIZATION AND MULTIPLET EFFECT IN COUPLED SPIN SYSTEMS BY TWO-DIMENSIONAL CIDNP [J].

BOELENS, R ;

PODOPLELOV, A ;

KAPTEIN, R .

JOURNAL OF MAGNETIC RESONANCE, 1986, 69 (01) :116-123

[6] TRANSFORMATION OF SYMMETRIZATION ORDER TO NUCLEAR-SPIN MAGNETIZATION BY CHEMICAL-REACTION AND NUCLEAR-MAGNETIC-RESONANCE [J].

BOWERS, CR ;

WEITEKAMP, DP .

PHYSICAL REVIEW LETTERS, 1986, 57 (21) :2645-2648

[7] PARA-HYDROGEN AND SYNTHESIS ALLOW DRAMATICALLY ENHANCED NUCLEAR ALIGNMENT [J].

BOWERS, CR ;

WEITEKAMP, DP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (18) :5541-5542

[8] A CONVENIENT GENERAL-SYNTHESIS OF TRANS-[IRCL(CO)(PR3)2] [J].

BURK, MJ ;

CRABTREE, RH .

INORGANIC CHEMISTRY, 1986, 25 (07) :931-932

[9] Para-hydrogen enrichment and hyperpolarization [J].

Canet, Daniel ;

Aroulanda, Christie ;

Mutzenhardt, Pierre ;

Aime, Silvio ;

Gobetto, Roberto ;

Reineri, Francesca .

CONCEPTS IN MAGNETIC RESONANCE PART A, 2006, 28A (05) :321-330

[10] PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy [J].

Chekmenev, Eduard Y. ;

Hoevener, Jan ;

Norton, Valerie A. ;

Harris, Kent ;

Batchelder, Lynne S. ;

Bhattacharya, Pratip ;

Ross, Brian D. ;

Weitekamp, Daniel P. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (13) :4212-+

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