Genetics of asthma and allergy: What have we learned?

被引：43

作者：

不详

机构：

[1] Center for Human Genomics and Personalized Medicine, Translational Sciences and Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, Medical Center Blvd

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2010年 / 126卷 / 03期

关键词：

Asthma; asthma genetics; genetics; genome-wide association study; genomics; IgE;

D O I：

10.1016/j.jaci.2010.07.012

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The overall purpose of this review is to present an update on genetic approaches to understanding the susceptibility and expression (severity) of common diseases, such as asthma and allergy. Five key questions are addressed in this review: (1) What phenotypes are being studied? Multiple disease phenotypes in carefully characterized patients are required. (2) Are the same genes that are important in disease susceptibility important in disease severity? (3) Are there racial differences in disease expression and genetic susceptibility? (4) Are the genes important in normal variation in lung function important in asthma severity? (5) Are the genes important in other common diseases, such as chronic inflammatory diseases or chronic obstructive pulmonary disease, important in asthma or allergy? In addition, a discussion of some of current areas of research is presented, including the issue that current genome-wide association study results do not account for a significant portion of trait variability, the potential role of rare variants and large genome-sequencing studies, and pharmacogenetics: is there a role for basing treatment decisions on the results of genetic testing? Finally, the potential usefulness of DNA, personalized medicine, is discussed. (J Allergy Clin Immunol 2010;126:439-46.)

引用

页码：447 / 448

页数：2

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