Activatable Hybrid Nanotheranostics for Tetramodal Imaging and Synergistic Photothermal/Photodynamic Therapy

被引：164

作者：

Goel, Shreya ^{[1
]}

Ferreira, Carolina A. ^{[2
]}

Chen, Feng ^{[3
]}

Ellison, Paul A. ^{[4
]}

Siamof, Cerise M. ^{[3
]}

Barnhart, Todd E. ^{[4
]}

Cai, Weibo ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Wisconsin, Dept Mat Sci & Engn, Madison, WI 53705 USA

[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA

[3] Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA

[4] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

[5] Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53705 USA

来源：

ADVANCED MATERIALS | 2018年 / 30卷 / 06期

基金：

美国国家卫生研究院;

关键词：

cancer theranostics; core-satellite nanoparticles; multimodal imaging; synergistic therapy; MESOPOROUS SILICA NANOPARTICLES; COPPER SULFIDE NANOPARTICLES; CERENKOV RADIATION; CANCER;

D O I：

10.1002/adma.201704367

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multifunctional core-satellite nanoconstruct is designed by assembling copper sulfide (CuS) nanoparticles on the surface of [Zr-89]-labeled hollow mesoporous silica nanoshells filled with porphyrin molecules, for effective cancer imaging and therapy. The hybrid nanotheranostic demonstrates three significant features: (1) simple and robust construction from biocompatible building blocks, demonstrating prolonged blood retention, enhanced tumor accumulation, and minimal long-term systemic toxicity, (2) rationally selected functional moieties that interact together to enable simultaneous tetramodal (positron emission tomography/fluorescence/Cerenkov luminescence/Cerenkov radiation energy transfer) imaging for rapid and accurate delineation of tumors and multimodal image-guided therapy in vivo, and (3) synergistic interaction between CuS-mediated photothermal therapy and porphyrin-mediated photodynamic therapy which results in complete tumor elimination within a day of treatment with no visible recurrence or side effects. Overall, this proof-of-concept study illustrates an efficient, generalized approach to design high-performance core-satellite nanohybrids that can be easily tailored to combine a wide variety of imaging and therapeutic modalities for improved and personalized cancer theranostics in the future.

引用

页数：9