Bile Acids in Neurodegenerative Disorders

被引：83

作者：

Ackerman, Hayley D. ^{[1
]}

Gerhard, Glenn S. ^{[1
]}

机构：

[1] Temple Univ, Dept Med Genet & Mol Biochem, Lewis Katz Sch Med, Philadelphia, PA 19122 USA

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2016年 / 8卷

关键词：

bile acids; neuroprotection; neurodegeneration; TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID; MOUSE MODEL; CELL-DEATH; 3-NITROPROPIONIC ACID; RETINAL DEGENERATION; THERAPEUTIC TARGET; POTENTIAL ROLE; TUDCA; APOPTOSIS;

D O I：

10.3389/fnagi.2016.00263

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Bile acids, a structurally related group of molecules derived from cholesterol, have a long history as therapeutic agents in medicine, from treatment for primarily ocular diseases in ancient Chinese medicine to modern day use as approved drugs for certain liver diseases. Despite evidence supporting a neuroprotective role in a diverse spectrum of age-related neurodegenerative disorders, including several small pilot clinical trials, little is known about their molecular mechanisms or their physiological roles in the nervous system. We review the data reported for their use as treatments for neurodegenerative diseases and their underlying molecular basis. While data from cellular and animal models and clinical trials support potential efficacy to treat a variety of neurodegenerative disorders, the relevant bile acids, their origin, and the precise molecular mechanism(s) by which they confer neuroprotection are not known delaying translation to the clinical setting.

引用

页数：13

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