Characterization of isolated tau-reactive antibodies from the IVIG product, plasma of patients with Alzheimer's disease and cognitively normal individuals

被引：11

作者：

Krestova, Michala ^{[1
,2
]}

Hromadkova, Lenka ^{[1
,3
,4
]}

Bilkova, Zuzana ^{[4
]}

Bartos, Ales ^{[1
,2
]}

Ricny, Jan ^{[1
]}

机构：

[1] Natl Inst Mental Hlth, Klecany, Czech Republic

[2] Charles Univ Prague, Fac Med 3, Prague, Czech Republic

[3] Charles Univ Prague, Fac Sci, Prague, Czech Republic

[4] Univ Pardubice, Dept Biol & Biochem Sci, Pardubice, Czech Republic

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 313卷

关键词：

Alzheimer's disease; Brain homogenates; Plasma antibodies; Reactivity profile; Tau protein; INTRAVENOUS IMMUNOGLOBULIN PRODUCTS; NATURALLY-OCCURRING AUTOANTIBODIES; NEUROFIBRILLARY TANGLES; NEURONAL-ACTIVITY; PATHOLOGICAL TAU; ENDOGENOUS TAU; AMYLOID-BETA; A-BETA; IMMUNOTHERAPY; PROTEIN;

D O I：

10.1016/j.jneuroim.2017.09.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence of natural tau-reactive antibodies was reported in human blood. In this study, we isolated and characterized natural tau-reactive antibodies occurring in IVIG product Flebogamma, plasma of patients with Alzheimer's disease (AD) and older cognitively normal persons (controls). Using blotting immunoassays and ELISA, we showed reactivity of antibodies obtained from IVIG and controls against a recombinant fragment of tau (155-421 aa) and aggregates present in brains of AD patients. In contrast, antibodies isolated from plasma of AD patients reacted mainly with the recombinant full-length tau form and tau monomeric forms in brain tissue.

引用

页码：16 / 24

页数：9

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