Characterization of isolated tau-reactive antibodies from the IVIG product, plasma of patients with Alzheimer's disease and cognitively normal individuals

被引：11

作者：

Krestova, Michala ^{[1
,2
]}

Hromadkova, Lenka ^{[1
,3
,4
]}

Bilkova, Zuzana ^{[4
]}

Bartos, Ales ^{[1
,2
]}

Ricny, Jan ^{[1
]}

机构：

[1] Natl Inst Mental Hlth, Klecany, Czech Republic

[2] Charles Univ Prague, Fac Med 3, Prague, Czech Republic

[3] Charles Univ Prague, Fac Sci, Prague, Czech Republic

[4] Univ Pardubice, Dept Biol & Biochem Sci, Pardubice, Czech Republic

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 313卷

关键词：

Alzheimer's disease; Brain homogenates; Plasma antibodies; Reactivity profile; Tau protein; INTRAVENOUS IMMUNOGLOBULIN PRODUCTS; NATURALLY-OCCURRING AUTOANTIBODIES; NEUROFIBRILLARY TANGLES; NEURONAL-ACTIVITY; PATHOLOGICAL TAU; ENDOGENOUS TAU; AMYLOID-BETA; A-BETA; IMMUNOTHERAPY; PROTEIN;

D O I：

10.1016/j.jneuroim.2017.09.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence of natural tau-reactive antibodies was reported in human blood. In this study, we isolated and characterized natural tau-reactive antibodies occurring in IVIG product Flebogamma, plasma of patients with Alzheimer's disease (AD) and older cognitively normal persons (controls). Using blotting immunoassays and ELISA, we showed reactivity of antibodies obtained from IVIG and controls against a recombinant fragment of tau (155-421 aa) and aggregates present in brains of AD patients. In contrast, antibodies isolated from plasma of AD patients reacted mainly with the recombinant full-length tau form and tau monomeric forms in brain tissue.

引用

页码：16 / 24

页数：9

共 50 条

[11] Pre-amyloid stage of Alzheimer's disease in cognitively normal individuals [J].

Tijms, Betty M. ;

Vermunt, Lisa ;

Zwan, Marissa D. ;

van Harten, Argonde C. ;

van der Flier, Wiesje M. ;

Teunissen, Charlotte E. ;

Scheltens, Philip ;

Visser, Pieter Jelle .

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2018, 5 (09) :1037-1047

[12] Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease [J].

Chatterjee, Pratishtha ;

Elmi, Mitra ;

Goozee, Kathryn ;

Shah, Tejal ;

Sohrabi, Hamid R. ;

Dias, Cintia B. ;

Pedrini, Steve ;

Shen, Kaikai ;

Asih, Prita R. ;

Dave, Preeti ;

Taddei, Kevin ;

Vanderstichele, Hugo ;

Zetterberg, Henrik ;

Blennow, Kaj ;

Martins, Ralph N. .

JOURNAL OF ALZHEIMERS DISEASE, 2019, 71 (03) :775-783

[13] Evaluation of Imaging Windows for Tau PET Imaging Using 18F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer's Disease Patients [J].

Chotipanich, Chanisa ;

Nivorn, Monchaya ;

Kunawudhi, Anchisa ;

Promteangtrong, Chetsadaporn ;

Boonkawin, Natphimol ;

Jantarato, Attapon .

MOLECULAR IMAGING, 2020, 19

[14] Relationships Between Tau and Glucose Metabolism Reflect Alzheimer's Disease Pathology in Cognitively Normal Older Adults [J].

Adams, Jenna N. ;

Lockhart, Samuel N. ;

Li, Lexin ;

Jagust, William J. .

CEREBRAL CORTEX, 2019, 29 (05) :1997-2009

[15] Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease [J].

Vergallo, Andrea ;

Megret, Lucile ;

Lista, Simone ;

Cavedo, Enrica ;

Zetterberg, Henrik ;

Blennow, Kaj ;

Vanmechelen, Eugeen ;

De Vos, Ann ;

Habert, Marie-Odile ;

Potier, Marie-Claude ;

Dubois, Bruno ;

Neri, Christian ;

Hampel, Harald ;

Dubois, B. ;

Hampel, H. ;

Bakardjian, H. ;

Benali, H. ;

Colliot, O. ;

Marie-O, Habert ;

Lamari, F. ;

Mochel, F. ;

Potier, M. C. ;

de Schotten, Thiebaut M. ;

Afshar, Mohammad ;

Aguilar, Lisi Flores ;

Akman-Anderson, Leyla ;

Arenas, Joaquin ;

Avila, Jesus ;

Babiloni, Claudio ;

Baldacci, Filippo ;

Batrla, Richard ;

Benda, Norbert ;

Black, Keith L. ;

Bokde, Arun L. W. ;

Bonuccelli, Ubaldo ;

Broich, Karl ;

Cacciola, Francesco ;

Caraci, Filippo ;

Castrillo, Juan ;

Cavedo, Enrica ;

Ceravolo, Roberto ;

Chiesa, Patrizia A. ;

Corvol, Jean-Christophe ;

Cuello, Augusto Claudio ;

Cummings, Jeffrey L. ;

Depypere, Herman ;

Dubois, Bruno ;

Duggento, Andrea ;

Emanuele, Enzo ;

Escott-Price, Valentina .

ALZHEIMERS & DEMENTIA, 2019, 15 (06) :764-775

[16] Cerebrospinal Fluid Amyloid-β 42, Total Tau and Phosphorylated Tau are Low in Patients with Normal Pressure Hydrocephalus: Analogies and Differences with Alzheimer's Disease [J].

Santangelo, Roberto ;

Cecchetti, Giordano ;

Bernasconi, Maria Paola ;

Cardamone, Rosalinda ;

Barbieri, Alessandra ;

Pinto, Patrizia ;

Passerini, Gabriella ;

Scomazzoni, Francesco ;

Comi, Giancarlo ;

Magnani, Giuseppe .

JOURNAL OF ALZHEIMERS DISEASE, 2017, 60 (01) :183-199

[17] Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer's disease spectrum patients [J].

Shigemoto, Yoko ;

Sone, Daichi ;

Maikusa, Norihide ;

Okamura, Nobuyuki ;

Furumoto, Shozo ;

Kudo, Yukitsuka ;

Ogawa, Masayo ;

Takano, Harumasa ;

Yokoi, Yuma ;

Sakata, Masuhiro ;

Tsukamoto, Tadashi ;

Kato, Koichi ;

Sato, Noriko ;

Matsuda, Hiroshi .

BRAIN AND BEHAVIOR, 2018, 8 (12)

[18] Computerized Cognitive Tests Are Associated with Biomarkers of Alzheimer's Disease in Cognitively Normal Individuals 10 Years Prior [J].

Soldan, Anja ;

Pettigrew, Corinne ;

Moghekar, Abhay ;

Albert, Marilyn .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2016, 22 (10) :968-977

[19] Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers [J].

Singh, Ayush ;

Allen, Dyron ;

Fracassi, Anna ;

Tumurbaatar, Batbayar ;

Natarajan, Chandramouli ;

Scaduto, Pietro ;

Woltjer, Randy ;

Kayed, Rakez ;

Limon, Agenor ;

Krishnan, Balaji ;

Taglialatela, Giulio .

JOURNAL OF ALZHEIMERS DISEASE, 2020, 78 (04) :1661-1678

[20] Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative [J].

Anna Zettergren ;

Jodie Lord ;

Nicholas J. Ashton ;

Andrea L. Benedet ;

Thomas K. Karikari ;

Juan Lantero Rodriguez ;

Anniina Snellman ;

Marc Suárez-Calvet ;

Petroula Proitsi ;

Henrik Zetterberg ;

Kaj Blennow .

Alzheimer's Research & Therapy, 13

← 1 2 3 4 5 →