Characterization of isolated tau-reactive antibodies from the IVIG product, plasma of patients with Alzheimer's disease and cognitively normal individuals

被引：10

作者：

Krestova, Michala ^{[1
,2
]}

Hromadkova, Lenka ^{[1
,3
,4
]}

Bilkova, Zuzana ^{[4
]}

Bartos, Ales ^{[1
,2
]}

Ricny, Jan ^{[1
]}

机构：

[1] Natl Inst Mental Hlth, Klecany, Czech Republic

[2] Charles Univ Prague, Fac Med 3, Prague, Czech Republic

[3] Charles Univ Prague, Fac Sci, Prague, Czech Republic

[4] Univ Pardubice, Dept Biol & Biochem Sci, Pardubice, Czech Republic

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 313卷

关键词：

Alzheimer's disease; Brain homogenates; Plasma antibodies; Reactivity profile; Tau protein; INTRAVENOUS IMMUNOGLOBULIN PRODUCTS; NATURALLY-OCCURRING AUTOANTIBODIES; NEUROFIBRILLARY TANGLES; NEURONAL-ACTIVITY; PATHOLOGICAL TAU; ENDOGENOUS TAU; AMYLOID-BETA; A-BETA; IMMUNOTHERAPY; PROTEIN;

D O I：

10.1016/j.jneuroim.2017.09.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence of natural tau-reactive antibodies was reported in human blood. In this study, we isolated and characterized natural tau-reactive antibodies occurring in IVIG product Flebogamma, plasma of patients with Alzheimer's disease (AD) and older cognitively normal persons (controls). Using blotting immunoassays and ELISA, we showed reactivity of antibodies obtained from IVIG and controls against a recombinant fragment of tau (155-421 aa) and aggregates present in brains of AD patients. In contrast, antibodies isolated from plasma of AD patients reacted mainly with the recombinant full-length tau form and tau monomeric forms in brain tissue.

引用

页码：16 / 24

页数：9

共 50 条

[11] Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals
Berti, V.
Murray, J.
Davies, M.
Spector, N.
Tsui, W. H.
Li, Y.
Williams, S.
Pirraglia, E.
Vallabhajosula, S.
McHugh, P.
Pupi, A.
de Leon, M. J.
Mosconi, L.
JOURNAL OF NUTRITION HEALTH & AGING, 2015, 19 (04) : 413 - 423
[12] Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease
Chatterjee, Pratishtha
Elmi, Mitra
Goozee, Kathryn
Shah, Tejal
Sohrabi, Hamid R.
Dias, Cintia B.
Pedrini, Steve
Shen, Kaikai
Asih, Prita R.
Dave, Preeti
Taddei, Kevin
Vanderstichele, Hugo
Zetterberg, Henrik
Blennow, Kaj
Martins, Ralph N.
JOURNAL OF ALZHEIMERS DISEASE, 2019, 71 (03) : 775 - 783
[13] Evaluation of Imaging Windows for Tau PET Imaging Using 18F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer's Disease Patients
Chotipanich, Chanisa
Nivorn, Monchaya
Kunawudhi, Anchisa
Promteangtrong, Chetsadaporn
Boonkawin, Natphimol
Jantarato, Attapon
MOLECULAR IMAGING, 2020, 19
[14] Relationships Between Tau and Glucose Metabolism Reflect Alzheimer's Disease Pathology in Cognitively Normal Older Adults
Adams, Jenna N.
Lockhart, Samuel N.
Li, Lexin
Jagust, William J.
CEREBRAL CORTEX, 2019, 29 (05) : 1997 - 2009
[15] Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease
Vergallo, Andrea
Megret, Lucile
Lista, Simone
Cavedo, Enrica
Zetterberg, Henrik
Blennow, Kaj
Vanmechelen, Eugeen
De Vos, Ann
Habert, Marie-Odile
Potier, Marie-Claude
Dubois, Bruno
Neri, Christian
Hampel, Harald
Dubois, B.
Hampel, H.
Bakardjian, H.
Benali, H.
Colliot, O.
Marie-O, Habert
Lamari, F.
Mochel, F.
Potier, M. C.
de Schotten, Thiebaut M.
Afshar, Mohammad
Aguilar, Lisi Flores
Akman-Anderson, Leyla
Arenas, Joaquin
Avila, Jesus
Babiloni, Claudio
Baldacci, Filippo
Batrla, Richard
Benda, Norbert
Black, Keith L.
Bokde, Arun L. W.
Bonuccelli, Ubaldo
Broich, Karl
Cacciola, Francesco
Caraci, Filippo
Castrillo, Juan
Cavedo, Enrica
Ceravolo, Roberto
Chiesa, Patrizia A.
Corvol, Jean-Christophe
Cuello, Augusto Claudio
Cummings, Jeffrey L.
Depypere, Herman
Dubois, Bruno
Duggento, Andrea
Emanuele, Enzo
Escott-Price, Valentina
ALZHEIMERS & DEMENTIA, 2019, 15 (06) : 764 - 775
[16] Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer's disease spectrum patients
Shigemoto, Yoko
Sone, Daichi
Maikusa, Norihide
Okamura, Nobuyuki
Furumoto, Shozo
Kudo, Yukitsuka
Ogawa, Masayo
Takano, Harumasa
Yokoi, Yuma
Sakata, Masuhiro
Tsukamoto, Tadashi
Kato, Koichi
Sato, Noriko
Matsuda, Hiroshi
BRAIN AND BEHAVIOR, 2018, 8 (12):
[17] Computerized Cognitive Tests Are Associated with Biomarkers of Alzheimer's Disease in Cognitively Normal Individuals 10 Years Prior
Soldan, Anja
Pettigrew, Corinne
Moghekar, Abhay
Albert, Marilyn
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2016, 22 (10) : 968 - 977
[18] Cerebrospinal Fluid Amyloid-β 42, Total Tau and Phosphorylated Tau are Low in Patients with Normal Pressure Hydrocephalus: Analogies and Differences with Alzheimer's Disease
Santangelo, Roberto
Cecchetti, Giordano
Bernasconi, Maria Paola
Cardamone, Rosalinda
Barbieri, Alessandra
Pinto, Patrizia
Passerini, Gabriella
Scomazzoni, Francesco
Comi, Giancarlo
Magnani, Giuseppe
JOURNAL OF ALZHEIMERS DISEASE, 2017, 60 (01) : 183 - 199
[19] Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
Singh, Ayush
Allen, Dyron
Fracassi, Anna
Tumurbaatar, Batbayar
Natarajan, Chandramouli
Scaduto, Pietro
Woltjer, Randy
Kayed, Rakez
Limon, Agenor
Krishnan, Balaji
Taglialatela, Giulio
JOURNAL OF ALZHEIMERS DISEASE, 2020, 78 (04) : 1661 - 1678
[20] Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging Initiative
Zettergren, Anna
Lord, Jodie
Ashton, Nicholas J.
Benedet, Andrea L.
Karikari, Thomas K.
Rodriguez, Juan Lantero
Snellman, Anniina
Suarez-Calvet, Marc
Proitsi, Petroula
Zetterberg, Henrik
Blennow, Kaj
ALZHEIMERS RESEARCH & THERAPY, 2021, 13 (01)

← 1 2 3 4 5 →