A Rh(III)-Catalyzed Cascade C-H Functionalization/C(sp3)-C(sp3) Formation/Cyclization Reaction for the Synthesis of Isoquinolinedione Derivatives

被引：3

作者：

Bai, Peng ^{[1
]}

Huang, Kenneth L. ^{[2
]}

Huang, Zhi-Zhen ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China

[2] Lakeside High Sch, 533 Blue Ridge Dr, Augusta, GA 30809 USA

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 24期

基金：

中国国家自然科学基金;

关键词：

cascade; C-H functionalization; C(sp(3))-C(sp(3)) bond; rhodium(III) catalysis; synthesis; ALPHA-DIAZOCARBONYL COMPOUNDS; INTERMOLECULAR CARBENOID FUNCTIONALIZATION; DIAZO-COMPOUNDS; N BOND; ORGANIC-SYNTHESIS; METAL CARBENE; ACTIVATION; INSERTION; BENZAMIDES; C(SP(3))-H;

D O I：

10.1055/s-0036-1588566

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cascade C-H functionalization/C(sp(3))-C(sp(3)) formation/cyclization reaction of N-methoxybenzamides with diazomalonates under rhodium(III) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp(2))-C(sp(3)) and C(sp(3))-C(sp(3)) bonds by rhodium(III) catalysis is also proposed.

引用

页码：5357 / 5363

页数：7

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