MAGE-A family: Attractive targets for cancer immunotherapy

被引：99
作者：
Sang, Meixiang [1 ,2 ]
Lian, Yishui [1 ]
Zhou, Xinliang [1 ]
Shan, Baoen [1 ,2 ]
机构：
[1] Hebei Med Univ, Hosp 4, Res Ctr, Shijiazhuang 050017, Hebei, Peoples R China
[2] Hebei Med Univ, Hosp 4, Tumor Res Inst, Shijiazhuang 050017, Hebei, Peoples R China
来源：
VACCINE | 2011年 / 29卷 / 47期
关键词：
Cancer/testis antigens; MAGE-A; Cancer immunotherapy; GENE-EXPRESSION; TUMOR-ANTIGENS; CANCER/TESTIS ANTIGENS; TESTIS ANTIGENS; CELL CARCINOMA; ANTIBODY; 57B; MELANOMA; IDENTIFICATION; APOPTOSIS; PROTEINS;
D O I：
10.1016/j.vaccine.2011.09.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The melonoma-associated antigens family A (MACE-A) belongs to cancer/testis antigens (CTA) that are expressed in a wide variety of malignant tumors but not in normal adult tissues except for testis. Interestingly, germ cells do not express MHC class I antigen, implying that these gene products should be ideal targets for cancer immunotherapy. The strict tumor-specific expression of MACE-As has led to several immunotherapeutic trials targeting some of these proteins. In this review, we briefly described the expression and activation mechanism of MACE-As in cancer. We also summarized the biological functions of MACE-As in cell progress and the progress of the cancer immunotherapy targeting MACE-A family. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8496 / 8500
页数：5
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