Immunogenicity of BNT162b2 vaccine booster againstSARS-CoV-2 Delta and Omicron variants in nursinghome residents: A prospective observational study inolder adults aged from 68 to 98 years

被引：20

作者：

Alidjinou, Enagnon Kazali ^{[1
]}

Demaret, Julie ^{[2
]}

Corroyer-Simovic, Benedicte ^{[3
]}

Labreuche, Julien ^{[4
]}

Goffard, Anne ^{[5
,6
]}

Trauet, Jacques ^{[2
]}

Lupau, Daniela ^{[2
]}

Miczek, Sophie ^{[7
]}

Vuotto, Fanny ^{[8
]}

Dendooven, Arnaud ^{[2
]}

Huvent-Grelle, Dominique ^{[3
]}

Podvin, Juliette ^{[3
]}

Dreuil, Daniel ^{[3
]}

Faure, Karine ^{[8
]}

Deplanque, Dominique ^{[9
]}

Bocket, Laurence ^{[1
]}

Duhamel, Alain ^{[10
]}

Sobaszek, Annie ^{[11
]}

Hober, Didier ^{[1
]}

Hisbergues, Michael ^{[12
]}

Puisieux, Francois ^{[3
]}

Autran, Brigitte ^{[13
,14
]}

Yazdanpanah, Yazdan ^{[15
]}

Labalette, Myriam ^{[2
]}

Lefevre, Guillaume ^{[2
]}

机构：

[1] CHU Lille, Lab Virol ULR3610, Univ Lille, F-59000 Lille, France

[2] Univ Lille, CHU Lille, Inst Immunol, U1286 Infinite Inst Translat Res Inflammat,Inserm, F-59000 Lille, France

[3] Univ Lille, CHU Lille, Hop Geriatr Bateliers, Pole Geriatrie, F-59000 Lille, France

[4] CHU Lille, Dept Biostat, F-59000 Lille, France

[5] Univ Lille, CIIL U1019 CIIL Ctr Infect & Immunite Lille, Ctr Infect & Immunite Lille, CNRS,Inserm,CHU Lille,Inst Pasteur Lille,U1019,UM, F-59000 Lille, France

[6] Inst Pasteur, Clin Microbiol Unit, F-59000 Lille, France

[7] CHU Lille, Med & Sante Travail, F-59000 Lille, France

[8] CHU Lille, Dept Malad Infect, F-59000 Lille, France

[9] Univ Lille, CHU Lille, Inserm, CIC 1403 Clin Invest Ctr, F-59000 Lille, France

[10] Univ Lille, EA 2694 Sante Publ Epidemiol & Qualite Soins, CHU Lille, Lille, Hauts De France, France

[11] Univ Lille, ULR 4483, Med & Sante Travail, IMPECS,CHU Lille, F-59000 Lille, France

[12] Univ Lille, Ctr Ressources Biol, CHU Lille, F-59000 Lille, France

[13] Sorbonne Univ, Paris, France

[14] CIMI Paris Ctr Rech Immunite Malad Infect, UMR S Inserm UPMC 1135, Paris, France

[15] Hop Bichat Claude Bernard, Infect Dis Dept, IAME, INSERM, Paris, France

来源：

LANCET REGIONAL HEALTH-EUROPE | 2022年 / 17卷

关键词：

BNT162b2; vaccine; Boost; SARS-CoV-2; Delta; Omicron; Older people; immunogenicity; FRAILTY;

D O I：

10.1016/j.lanepe.2022.100385

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents. Methods In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers against Delta and Omicron variants were compared before and up to three months after the BNT162b2 booster dose, in NH residents without COVID-19 (COVID-19 naive) or with COVID-19 prior to initial vaccination (COVID-19 recovered). Findings 106 NH residents (median [interquartile range] age: 86.5 [81;91] years) were included. The booster dose induced a high increase of anti-spike antibody levels in all subjects (p < 0.0001) and a mild transient increase of specific T cells. Before the booster dose, Delta neutralization was detected in 19% (n = 8/43) and 88% (n = 37/42) of COVID-19 naive and COVID-19 recovered subjects, respectively. Three months after the booster dose, all NH residents developed and maintained a higher Delta neutralization (p < 0.0001). Before the booster dose, Omicron neutralization was detected in 5% (n = 2/43) and 55% (n = 23/42) of COVID-19 naive and COVID-19 recovered subjects, respectively, and three months after, in 84% and 95%, respectively. Neutralizing titers to Omicron were lower than to Delta in both groups with a 35-fold reduction compared to Delta. Interpretation The booster dose restores high neutralization titers against Delta in all NH residents, and at a lower level against Omicron in a large majority of participants. Future studies are warranted to assess if repeated BNT162b2 booster doses or new specific vaccines might be considered for protecting such fragile patients against Omicron and/or future SARS-CoV-2 variants. Copyright (C) 2022 The Authors. Published by Elsevier Ltd.

引用

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