Cancer metabolism;
Glutamine;
Inhibitor;
Synthesis;
KIDNEY-TYPE GLUTAMINASE;
NUCLEOTIDE-METABOLISM;
L-ASPARAGINASE;
CYSTINE UPTAKE;
SYSTEM XC(-);
CANCER-CELLS;
AMINO-ACIDS;
PHASE-I;
DEHYDROGENASE;
SULFASALAZINE;
D O I:
10.1016/j.ejmech.2018.11.066
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism. Among these metabolic features of cancers, glutamine metabolism has been reported to be the main energy supply for the growth and viability of a potentially large subset of malignant tumors. In addition, the significance of glutamine metabolism in cancer cells derives from the ability of donate its nitrogen and carbon atoms for the synthesis of important biologically substances. During recent years, emerging evidences have proved the inhibitors targeting glutamine metabolism pathway could be efficient anticancer drugs. Therefore, in this review, we would briefly introduce the regulation of glutamine metabolism, and then summarize the recent advances of small molecule modulators targeting various nodes in glutamine signaling pathway. The current potential obstacles and future therapeutic perspectives in glutamine metabolism are also put forward in order to provide reference for the drug discovery of novel and potent glutamine metabolism modulators. (C) 2018 Elsevier Masson SAS. All rights reserved.
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Jewell, Jenna L.
Kim, Young Chul
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Kim, Young Chul
Russell, Ryan C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Russell, Ryan C.
Yu, Fa-Xing
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Childrens Hosp, Shanghai 200032, Peoples R China
Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R ChinaUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Yu, Fa-Xing
Park, Hyun Woo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Park, Hyun Woo
Plouffe, Steven W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Plouffe, Steven W.
Tagliabracci, Vincent S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Tagliabracci, Vincent S.
Guan, Kun-Liang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Jin, Lingtao
Li, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Li, Dan
Alesi, Gina N.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Alesi, Gina N.
Fan, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Fan, Jun
论文数: 引用数:
h-index:
机构:
Kang, Hee-Bum
Lu, Zhou
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Chem, Chicago, IL 60637 USA
Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Lu, Zhou
Boggon, Titus J.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Pharmacol, New Haven, CT 06520 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Boggon, Titus J.
Jin, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Dept Human Genet, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Jin, Peng
Yi, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Robert P Apkarian Integrated Electron Microscopy, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Yi, Hong
Wright, Elizabeth R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Wright, Elizabeth R.
论文数: 引用数:
h-index:
机构:
Duc Duong
Seyfried, Nicholas T.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Seyfried, Nicholas T.
Egnatchik, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Egnatchik, Robert
DeBerardinis, Ralph J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
DeBerardinis, Ralph J.
Magliocca, Kelly R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Magliocca, Kelly R.
He, Chuan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Chem, Chicago, IL 60637 USA
Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
He, Chuan
Arellano, Martha L.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Arellano, Martha L.
Khoury, Hanna J.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Khoury, Hanna J.
Shin, Dong M.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Shin, Dong M.
Khuri, Fadlo R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Khuri, Fadlo R.
Kang, Sumin
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Jewell, Jenna L.
Kim, Young Chul
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Kim, Young Chul
Russell, Ryan C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Russell, Ryan C.
Yu, Fa-Xing
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Childrens Hosp, Shanghai 200032, Peoples R China
Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R ChinaUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Yu, Fa-Xing
Park, Hyun Woo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Park, Hyun Woo
Plouffe, Steven W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Plouffe, Steven W.
Tagliabracci, Vincent S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Tagliabracci, Vincent S.
Guan, Kun-Liang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Jin, Lingtao
Li, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Li, Dan
Alesi, Gina N.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Alesi, Gina N.
Fan, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Fan, Jun
论文数: 引用数:
h-index:
机构:
Kang, Hee-Bum
Lu, Zhou
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Chem, Chicago, IL 60637 USA
Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Lu, Zhou
Boggon, Titus J.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Pharmacol, New Haven, CT 06520 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Boggon, Titus J.
Jin, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Dept Human Genet, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Jin, Peng
Yi, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Robert P Apkarian Integrated Electron Microscopy, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Yi, Hong
Wright, Elizabeth R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Wright, Elizabeth R.
论文数: 引用数:
h-index:
机构:
Duc Duong
Seyfried, Nicholas T.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Seyfried, Nicholas T.
Egnatchik, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Egnatchik, Robert
DeBerardinis, Ralph J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
DeBerardinis, Ralph J.
Magliocca, Kelly R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Magliocca, Kelly R.
He, Chuan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Chem, Chicago, IL 60637 USA
Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
He, Chuan
Arellano, Martha L.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Arellano, Martha L.
Khoury, Hanna J.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Khoury, Hanna J.
Shin, Dong M.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Shin, Dong M.
Khuri, Fadlo R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Khuri, Fadlo R.
Kang, Sumin
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA