The inhibitory effect of medroxyprogesterone acetate on steroid sulfatase in human uterine endometrial cancer cells

被引:6
作者
Yamamoto, T
Yokota, K
Urabe, M
Kitawaki, J
Honjo, H
机构
[1] Department of Obstetrics, Kyoto Pref. University of Medicine, Kamikyo-ku, Kyoto 602, Kawaramachi-Hirokoji
关键词
D O I
10.1677/erc.0.0030337
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The activity of estrone sulfatase (E(1)SF), which converts estrone sulfate to estrone, In uterine endometrial cancer tissue is remarkably high compared with endometrial tissues, and this is assumed to contribute to the growth of this tumor. Thus, in this study, in order to screen drugs for sulfatase inhibitor activity, the inhibitory effect of medroxyprogesterone acetate (MPA; which is widely used for advanced or recurrent endometrial cancer) on E(1)SF activity and steroid sulfatase (STS) gene expression in endometrial cancer cells was examined and compared with danazol (DZ). MPA and DZ were shown to inhibit E(1)SF activity dose-dependently in the established endometrial cancer cell lines (Ishikawa and HEC-59 strains). These drugs (10(-8) M) also inhibited the expression of STS mRNA, and this inhibition of STS gene expression is considered to partly explain their inhibitory actions against STS.
引用
收藏
页码:337 / 340
页数:4
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