GATA Factors in Gastrointestinal Malignancy

被引：27

作者：

Ayanbule, Funmi ^{[1
]}

Belaguli, Narasimhaswamy S. ^{[1
]}

Berger, David H. ^{[1
]}

机构：

[1] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Michael E DeBakey Dept Surg, Houston, TX 77030 USA

来源：

WORLD JOURNAL OF SURGERY | 2011年 / 35卷 / 08期

关键词：

MUCIN GENE-EXPRESSION; TRANSCRIPTION FACTORS GATA-4; SPASMOLYTIC POLYPEPTIDE PSP; DNA-BINDING PROTEIN; PLASMINOGEN-ACTIVATOR; BARRETTS-ESOPHAGUS; TREFOIL FACTOR; MICE LACKING; HUMAN-COLON; 15-LIPOXYGENASE-1; EXPRESSION;

D O I：

10.1007/s00268-010-0950-1

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

GATA factors are unique transcription factors with conserved DNA-binding domains. They serve diverse roles in embryogenesis, cell differentiation, regulation of tissue-specific genes, and carcinogenesis. The subfamily GATA-4, -5, and -6 are highly expressed in endoderm-derived organs and regulate multiple gut-specific genes. Multiple studies have analyzed the role of GATA factors in gastrointestinal (GI) malignancy, such as those of the stomach, pancreas, and colon, and premalignant lesions such as Barrett's esophagus. The GATA factors appear to have distinct roles in regulating key genes involved in GI malignancy. Understanding the precise role of GATA factors in malignancy may lead to the development of effective molecular targets for cancer therapy.

引用

页码：1757 / 1765

页数：9

共 124 条

[1] GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer [J].