Industry research on the use and effects of levulinic acid: A case study in cigarette additives

被引:38
作者
Keithly, L
Wayne, GF
Cullen, DM
Connolly, GN
机构
[1] Massachusetts Dept Publ Hlth, Tobacco Control Program, Boston, MA 02108 USA
[2] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[3] Massachusetts Dept Publ Hlth, Boston, MA USA
[4] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
关键词
D O I
10.1080/14622200500259820
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Public health officials and tobacco researchers have raised concerns about the possible contributions of additives to the toxicity of cigarettes. However, little attention has been given to the process whereby additives promote initiation and addiction. Levulinic acid is a known cigarette additive. Review of internal tobacco industry documents indicates that levulinic acid was used to increase nicotine yields while enhancing perceptions of smoothness and mildness. Levulinic acid reduces the pH of cigarette smoke and desensitizes the upper respiratory tract, increasing the potential for cigarette smoke to be inhaled deeper into the lungs. Levulinic acid also may enhance the binding of nicotine to neurons that ordinarily would be unresponsive to nicotine. These findings held particular interest in the internal development of ultralight and so-called reduced-exposure cigarette prototypes. Industry studies found significantly increased peak plasma nicotine levels in smokers of ultralight cigarettes following addition of levulinic acid. Further, internal studies observed changes in mainstream and sidestream smoke composition that may present increased health risks. The use of levulinic acid illustrates the need for regulatory authority over tobacco products as well as better understanding of the role of additives in cigarettes and other tobacco products.
引用
收藏
页码:761 / 771
页数:11
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