Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast

被引：31

作者：

Bilinski, Tomasz ^{[1
]}

Zadrag-Tecza, Renata ^{[1
]}

Bartosz, Grzegorz ^{[1
]}

机构：

[1] Univ Rzeszow, Dept Biochem & Cell Biol, PL-35601 Rzeszow, Poland

来源：

FEMS YEAST RESEARCH | 2012年 / 12卷 / 01期

关键词：

Saccharomyces cerevisiae; cell volume; replicative aging; budding; cell cycle; hypertrophy; SACCHAROMYCES-CEREVISIAE; LIFE-SPAN; DAUGHTER CELLS; LONGEVITY; VOLUME; AGE; CIRCLES; GROWTH; MODEL;

D O I：

10.1111/j.1567-1364.2011.00759.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This paper summarizes numerous arguments demonstrating that the hypothesis of accumulation of the senescence factor, which was the basis for introducing yeast to the group of model organisms of gerontology, finds no experimental support. Among several candidates for the role of the causative agents of replicative aging, only one hypertrophy always accompanies symptoms of aging, not only in Saccharomyces cerevisiae, but also in Schizosaccharomyces pombe.

引用

页码：97 / 101

页数：5

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