Ferroptosis-Related Gene MT1G as a Novel Biomarker Correlated With Prognosis and Immune Infiltration in Colorectal Cancer

被引:21
作者
Peng, Bi
Peng, Jinwu
Kang, Fanhua
Zhang, Wenqin
Peng, Emin
He, Qingchun
机构
[1] Department of Pathology, Xiangya Hospital, Central South University, Changsha
[2] Department of Pathology, Xiangya Changde Hospital, Changde
[3] Xiangya International Medical Center, Xiangya Hospital, Central South University, Changsha
[4] National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha
[5] Department of Emergency, Xiangya Hospital, Central South University, Changsha
[6] Department of Emergency, Xiangya Changde Hospital, Changde
关键词
colorectal cancer; ferroptosis; MT1G; prognosis; immune response; FANCONI-ANEMIA; COLON-CANCER; EXPRESSION; PATHWAY; CELLS;
D O I
10.3389/fcell.2022.881447
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ferroptosis, a newly discovered way of cell death, has been proved to be involved in the oncogenesis and development of cancers, including colorectal cancer (CRC). Here, by identifying the differentially expressed genes (DEGs) from three CRC transcriptome microarray datasets (GSE20842, GSE23878, and GSE25070), we found that the expression of MT1G was significantly decreased in CRC tissues, and the patients with a high level of MT1G displayed a poor prognosis. Quantitative PCR (qPCR) further confirmed the downregulated MT1G in two CRC cells, HCT8 and HCT116. The colony-forming assay indicated that the MT1G overexpression exhibited a remarkable inhibition of cell proliferation in HCT8 and HCT116 cells. In addition, we explored the co-expressed genes of MT1G to gain a better understanding of its potential signaling pathways. Aberrantly expressed MT1G also affected the immune response of CRC patients. Collectively, these findings might deepen our comprehension on the potential biological implications of MT1G in CRC.
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页数:10
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