Neutrophil Extracellular Traps in Candida albicans Infection

被引:29
作者
He, Yufei [1 ,2 ]
Liu, Jia [1 ]
Chen, Yutong [1 ]
Yan, Lan [2 ]
Wu, Jianhua [1 ]
机构
[1] Second Mil Med Univ, Changhai Hosp, Dept Dermatol, Naval Med Univ, Shanghai, Peoples R China
[2] Second Mil Med Univ, Naval Med Univ, Sch Pharm, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
neutrophils; neutrophil extracellular traps; Candida albicans; virulence factors; innate immunity; BETA-GLUCAN; INVASIVE CANDIDIASIS; MITOCHONDRIAL-DNA; INTEGRIN MAC-1; CELL-WALL; RELEASE; NETOSIS; RECOGNITION; MECHANISM; IMMUNITY;
D O I
10.3389/fimmu.2022.913028
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Candida albicans is the most common pathogen causing clinical Candida infections. Neutrophils are a key member of the host innate immunity that plays an essential role in clearing invading C. albicans. In addition to the well-known defensive approaches such as phagocytosis, degranulation, and reactive oxygen species production, the formation of neutrophil extracellular traps (NETs) has also become an important way for neutrophils to defend against various pathogens. C. albicans has been reported to be capable of activating neutrophils to release NETs that subsequently kill fungi. The induction of NETs is affected by both the morphology and virulence factors of C. albicans, which also develops specific strategies to respond to the attack by NETs. Our review specifically focuses on the mechanisms by which C. albicans triggers NET formation and their subsequent interactions, which might provide meaningful insight into the innate immunity against C. albicans infection.
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页数:7
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