Drug-induced thrombotic microangiopathy: Experience of the Oklahoma Registry and the BloodCenter of Wisconsin

被引:84
作者
Reese, Jessica A. [1 ]
Bougie, Daniel W. [2 ,3 ]
Curtis, Brian R. [2 ,3 ]
Terrell, Deirdra R. [1 ]
Vesely, Sara K. [1 ]
Aster, Richard H. [2 ,3 ]
George, James N. [1 ,4 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK 73190 USA
[2] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA
[3] BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI USA
[4] Univ Oklahoma, Hlth Sci Ctr, Hematol Oncol Sect, Dept Med,Coll Med, Oklahoma City, OK 73190 USA
基金
美国国家卫生研究院;
关键词
HEMOLYTIC-UREMIC SYNDROME; THROMBOCYTOPENIC PURPURA; IMMUNE THROMBOCYTOPENIA; QUININE; FEATURES; ABUSE; TTP;
D O I
10.1002/ajh.23960
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Many drugs have been reported to cause thrombotic microangiopathy (TMA), often described as thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome (HUS). We recently established criteria to evaluate the evidence for a causal association of a drug with TMA and then we systematically reviewed all published reports of drug-induced TMA (DITMA) to determine the level of evidence supporting a causal association of the suspected drug with TMA. On the basis of this experience, we used these evaluation criteria to assess the Oklahoma TTP-HUS Registry patients who had been previously categorized as drug-induced, 1989-2014. We also reviewed the experience of the BloodCenter of Wisconsin with testing for drug-dependent antibodies reactive with platelets and neutrophils in patients with suspected immune-mediated DITMA, 1988-2014. Among 58 patients in the Oklahoma Registry previously categorized as drug-induced (15 suspected drugs), 21 patients (three drugs: gemcitabine, pentostatin, quinine) had evidence supporting a definite association with TMA; 19 (90%) of the 21 patients had quinine-induced TMA. The BloodCenter of Wisconsin tested 40 patients with suspected DITMA (eight drugs); drug-dependent antibodies, supporting a definite association with TMA, were identified in 30 patients (three drugs: oxaliplatin, quinine, vancomycin); 28 (93%) of the 30 patients had quinine-induced TMA. Combining the data from these two sources, 51 patients (five drugs) have been identified with evidence supporting a definite association with TMA. DITMA was attributed to quinine in 47 (92%) of these 51 patients. Am. J. Hematol. 90:406-410, 2015. (c) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:406 / 410
页数:5
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