Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

被引：10

作者：

Ivanov, Alexey A. ^{[1
]}

Kuznetsova, Alla V. ^{[1
,2
]}

Popova, Olga P. ^{[1
]}

Danilova, Tamara I. ^{[1
]}

Yanushevich, Oleg O. ^{[3
]}

机构：

[1] AI Evdokimov Moscow State Univ Med & Dent, Lab Mol & Cellular Pathol, 20 Delegatskaya Str, Moscow 127473, Russia

[2] Russian Acad Sci, Koltzov Inst Dev Biol, 26 Vavilov Str, Moscow 119334, Russia

[3] AI Evdokimov Moscow State Univ Med & Dent, Dept Paradontol, 20 Delegatskaya Str, Moscow 127473, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 24期

关键词：

endogenous regenerative medicine; bone regeneration; dental regeneration; decellularized extracellular matrix; growth factors; extracellular vesicles; miRNAs; MESENCHYMAL STEM-CELLS; EXTRACELLULAR-MATRIX; OSTEOGENIC DIFFERENTIATION; MICRORNA EXPRESSION; CONDITIONED MEDIUM; STROMAL CELLS; BIOMATERIALS; EXOSOMES; MICROVESICLES; SCAFFOLD;

D O I：

10.3390/ijms222413454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homing of endogenous stem cells has advantages in overcoming the limitations and risks associated with cell therapy. In this review, we discuss the potential of cell-free products such as the decellularized extracellular matrix, growth factors, extracellular vesicles and miRNAs in endogenous bone and dental regeneration.

引用

页数：17

共 124 条

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