Whole Genome Sequencing: Revolutionary Medicine or Privacy Nightmare?

被引:29
|
作者
Ayday, Erman [1 ]
De Cristofaro, Emiliano [2 ]
Hubaux, Jean-Pierre [3 ]
Tsudik, Gene [4 ]
机构
[1] Bilkent Univ, Comp Sci, Ankara, Turkey
[2] UCL, London WC1E 6BT, England
[3] Ecole Polytech Fed Lausanne, Sch Comp & Commun Sci, CH-1015 Lausanne, Switzerland
[4] Univ Calif Irvine, Comp Sci, Irvine, CA USA
关键词
bioinformatics; computing in healthcare; computing in medicine; Genome sequencing; healthcare; medical computing; patient privacy; personalized medicine; privacy; security;
D O I
10.1109/MC.2015.59
中图分类号
TP3 [计算技术、计算机技术];
学科分类号
0812 ;
摘要
Whole genome sequencing will soon become affordable for many individuals, but thorny privacy and ethical issues could jeopardize its popularity and thwart the large-scale adoption of genomics in healthcare and slow potential medical advances. The Web extra at http://youtu.be/As3J9NYsbbY is an audio recording of Alf Weaver interviewing Bradley Malin and Jacques Fellay about the possibilities and challenges of whole genome sequencing. © 1970-2012 IEEE.
引用
收藏
页码:58 / 66
页数:9
相关论文
共 50 条
  • [2] Downsizing genomic medicine: Approaching the ethical complexity of whole-genome sequencing by starting small
    Sharp, Richard R.
    GENETICS IN MEDICINE, 2011, 13 (03) : 191 - 194
  • [3] Early technology assessment of using whole genome sequencing in personalized oncology
    Simons, Martijn
    van de Ven, Michiel
    Coupe, Veerle
    Joore, Manuela
    IJzerman, Maarten
    Koffijberg, Erik
    Frederix, Geert
    Uyl -De Groot, Carin
    Cuppen, Edwin
    Van Harten, Wim
    Retel, Valesca
    EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH, 2021, 21 (03) : 343 - 351
  • [4] Bioinformatics Workflow for Clinical Whole Genome Sequencing at Partners HealthCare Personalized Medicine
    Tsai, Ellen A.
    Shakbatyan, Rimma
    Evans, Jason
    Rossetti, Peter
    Graham, Chet
    Sharma, Himanshu
    Lin, Chiao-Feng
    Lebo, Matthew S.
    JOURNAL OF PERSONALIZED MEDICINE, 2016, 6 (01):
  • [5] The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine
    Vassy, Jason L.
    Lautenbach, Denise M.
    McLaughlin, Heather M.
    Kong, Sek Won
    Christensen, Kurt D.
    Krier, Joel
    Kohane, Isaac S.
    Feuerman, Lindsay Z.
    Blumenthal-Barby, Jennifer
    Roberts, J. Scott
    Lehmann, Lisa Soleymani
    Ho, Carolyn Y.
    Ubel, Peter A.
    MacRae, Calum A.
    Seidman, Christine E.
    Murray, Michael F.
    McGuire, Amy L.
    Rehm, Heidi L.
    Green, Robert C.
    TRIALS, 2014, 15
  • [6] Rapid Whole Genome Sequencing in Critically Ill Neonates Enables Precision Medicine Pipeline
    Beaman, Makenzie
    Fisher, Kimberley
    McDonald, Marie
    Tan, Queenie K. G.
    Jackson, David
    Cocanougher, Benjamin T.
    Landstrom, Andrew P.
    Hobbs, Charlotte A.
    Cotten, Michael
    Cohen, Jennifer L.
    JOURNAL OF PERSONALIZED MEDICINE, 2022, 12 (11):
  • [7] Leiomyosarcomas: whole genome sequencing for a whole biology characterization
    Chibon, Frederic
    Darbo, Elodie
    Perot, Gaelle
    CURRENT OPINION IN ONCOLOGY, 2019, 31 (04) : 317 - 321
  • [8] Whole-Genome Sequencing in Cancer
    Zhao, Eric Y.
    Jones, Martin
    Jones, Steven J. M.
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019, 9 (03):
  • [9] Strategies for whole microbial genome sequencing and analysis
    Fraser, CM
    Fleischmann, RD
    ELECTROPHORESIS, 1997, 18 (08) : 1207 - 1216
  • [10] Whole-genome sequencing of the UK Biobank
    Halldorsson, Bjarni, V
    Stefansson, Kari
    NATURE, 2022,