The characterization and structure-activity evaluation of toxic norditerpenoid alkaloids from two Delphinium species

被引：21
作者：
Manners, GD
Panter, KE
Pfister, JA
Ralphs, MH
James, LF
机构：
[1] ARS, Western Reg Res Ctr, USDA, Albany, CA 94706 USA
[2] ARS, Poisonous Plant Res Lab, USDA, Logan, UT USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 09期
关键词：
D O I：
10.1021/np980013e
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new N-(methylsuccinimido)anthranoyllycoctonin norditerpenoid alkaloid, geyerline, has been isolated and characterized from extracts of the poisonous larkspur Delphinium glaucum. A previously described norditerpenoid alkaloid, grandiflorine, has also been isolated from Delphinium geyeri. Both alkaloids are closely related structurally to the potent neurotoxin methyllycaconitine, established as the primary toxin in many larkspurs poisonous to cattle. Mouse bioassay tests showed grandiflorine to possess toxicity comparable to methyllycaconitine, while its synthetically derived monoacetate, grandiflorine acetate, and geyerline are significantly less toxic.
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页码：1086 / 1089
页数：4
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