Impact of pulmonary disease on patient-reported outcomes and patient-performed functional testing in systemic lupus erythematosus

被引:19
作者
Fidler, L. [1 ]
Keen, K. J. [2 ,3 ]
Touma, Z. [4 ,5 ,6 ]
Mittoo, S. [4 ,5 ,6 ]
机构
[1] Univ Toronto, Div Respirol, Dept Med, Toronto, ON, Canada
[2] Univ Northern British Columbia, Dept Math & Stat, Prince George, BC, Canada
[3] Univ Northern British Columbia, Hlth Res Inst, Prince George, BC, Canada
[4] Univ Toronto, Div Rheumatol, Dept Med, Toronto, ON, Canada
[5] Mt Sinai Hosp, Dept Med, Div Rheumatol, Toronto, ON, Canada
[6] Univ Hlth Network, Toronto, ON M5T 3L9, Canada
关键词
Lupus; pulmonary disease; six-minute walk test; patient reported outcomes; health-related quality of life; QUALITY-OF-LIFE; CIGARETTE-SMOKING; REVISED CRITERIA; SF-36; RECOMMENDATIONS; CLASSIFICATION; RELIABILITY; PREVALENCE; VALIDATION; VALIDITY;
D O I
10.1177/0961203316630818
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives This study examines the effect of pulmonary disease on patient-reported outcomes (PROs) and patient-performed outcome (PPO) in systemic lupus erythematosus (SLE) patients at a single tertiary referral center. Methods Pulmonary function tests (PFTs), chest imaging, SLE-related damage, and disease activity were examined in 110 SLE patients. Presence was noted of abnormal PFTs, pleural disease, pulmonary hypertension (PH), pulmonary infarction, interstitial lung disease (ILD), and shrinking lung syndrome (SLS). PROs included the Medical Outcome Short Form-36 Health Survey, Pittsburgh Sleep Quality Index, Fatigue Severity Scale, Borg Dyspnea Scale, patient dyspnea and cough. The PPO of interest was the six-minute walk test (6MWT). Relationships amongst PROs, 6MWT, and pulmonary disease were studied. Results Pulmonary disease was present in 62 (56%) of 110 subjects: 54 (49%) abnormal PFT, 13 (12%) pleural disease, 12 (11%) ILD, 11 (10%) SLS and five (5%) PH. Dyspnea was the only PRO found to be significantly associated with pulmonary disease (P=0.0004). Participants with pulmonary disease compared to those without had significantly reduced distance (P=0.00015, 95% CI for mean 39-125m) and predicted distance (P=0.00001, 10%-26%) on 6MWT. Conclusions Pulmonary disease is common in SLE and adversely impacts 6MWT distance and dyspnea without apparent influence on other PROs. The 6MWT may be a promising tool in the assessment of pulmonary disease in SLE.
引用
收藏
页码:1004 / 1011
页数:8
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