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Topical 1% 5-fluorouracil in ocular surface squamous neoplasia: a long-term safety study
被引:62
作者:
Parrozzani, Raffaele
[2
]
Lazzarini, Daniela
[2
]
Alemany-Rubio, Ernesto
[1
,3
]
Urban, Francesca
[1
]
Midena, Edoardo
[1
,2
]
机构:
[1] Univ Padua, Dept Ophthalmol, I-35128 Padua, Italy
[2] IRCCS, Fdn GB Bietti Oftalmol, Rome, Italy
[3] Univ Habana, Cuban Eye Inst, Havana, Cuba
关键词:
CONJUNCTIVAL INTRAEPITHELIAL NEOPLASIA;
CELL CARCINOMA;
MITOMYCIN-C;
CONFOCAL MICROSCOPY;
CORNEAL THICKNESS;
D O I:
10.1136/bjo.2010.183244
中图分类号:
R77 [眼科学];
学科分类号:
100212 ;
摘要:
Background/aims The aim of this study was to evaluate the long-term corneal toxicity of topical chemotherapy with 1% 5-fluorouracil (5-FU) as a sole or adjuvant treatment of ocular surface squamous neoplasia (OSSN). Methods Forty-one consecutive cases of OSSN were included in this prospective study. Patients underwent topical chemotherapy with 1% 5-FU four times/day for 4 weeks (one course). Adjunctive courses were repeated until clinical and cytological tumour regression. Clinical confocal microscopy was used to check for 5-FU long-term corneal toxicity. Results Mean follow-up was 89.7 +/- 14.4 months (range 63-122 months). Twenty-two patients (53.7%) underwent topical 5-FU as a sole treatment, and 19 patients (46.3%) as adjuvant and/or debulking therapy. The mean number of 5-FU cycles was 1.9 (range 1-5 cycles). Three tumours (7.3%) treated with 5-FU alone recurred during follow-up. Recurrences were successfully treated with additional 5-FU courses. Clinical confocal microscopy showed no long-term difference between the treated eye and fellow (control) eye in: endothelial cells count, pleomorphism and polymegatism, anterior stromal keratocyte density, sub-basal nerve plexus fibre number, density, and beadings and central cornea epithelium thickness (p=NS). Conclusion Topical 5-FU, as a sole or combined therapy, must be considered a long-term safe and effective treatment for patients affected by OSSN.
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页码:355 / 359
页数:5
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