Topical 1% 5-fluorouracil in ocular surface squamous neoplasia: a long-term safety study

被引:62
作者
Parrozzani, Raffaele [2 ]
Lazzarini, Daniela [2 ]
Alemany-Rubio, Ernesto [1 ,3 ]
Urban, Francesca [1 ]
Midena, Edoardo [1 ,2 ]
机构
[1] Univ Padua, Dept Ophthalmol, I-35128 Padua, Italy
[2] IRCCS, Fdn GB Bietti Oftalmol, Rome, Italy
[3] Univ Habana, Cuban Eye Inst, Havana, Cuba
关键词
CONJUNCTIVAL INTRAEPITHELIAL NEOPLASIA; CELL CARCINOMA; MITOMYCIN-C; CONFOCAL MICROSCOPY; CORNEAL THICKNESS;
D O I
10.1136/bjo.2010.183244
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Background/aims The aim of this study was to evaluate the long-term corneal toxicity of topical chemotherapy with 1% 5-fluorouracil (5-FU) as a sole or adjuvant treatment of ocular surface squamous neoplasia (OSSN). Methods Forty-one consecutive cases of OSSN were included in this prospective study. Patients underwent topical chemotherapy with 1% 5-FU four times/day for 4 weeks (one course). Adjunctive courses were repeated until clinical and cytological tumour regression. Clinical confocal microscopy was used to check for 5-FU long-term corneal toxicity. Results Mean follow-up was 89.7 +/- 14.4 months (range 63-122 months). Twenty-two patients (53.7%) underwent topical 5-FU as a sole treatment, and 19 patients (46.3%) as adjuvant and/or debulking therapy. The mean number of 5-FU cycles was 1.9 (range 1-5 cycles). Three tumours (7.3%) treated with 5-FU alone recurred during follow-up. Recurrences were successfully treated with additional 5-FU courses. Clinical confocal microscopy showed no long-term difference between the treated eye and fellow (control) eye in: endothelial cells count, pleomorphism and polymegatism, anterior stromal keratocyte density, sub-basal nerve plexus fibre number, density, and beadings and central cornea epithelium thickness (p=NS). Conclusion Topical 5-FU, as a sole or combined therapy, must be considered a long-term safe and effective treatment for patients affected by OSSN.
引用
收藏
页码:355 / 359
页数:5
相关论文
共 26 条
[1]   The clinical applications of fluorouracil in ophthalmic practice [J].
Abraham, Lekha M. ;
Selva, Dinesh ;
Casson, Robert ;
Leibovitch, Igal .
DRUGS, 2007, 67 (02) :237-255
[2]   Ocular surface squamous neoplasia - A review [J].
Basti, S ;
Macsai, MS .
CORNEA, 2003, 22 (07) :687-704
[3]   Central corneal thickness - Z-ring corneal confocal microscopy versus ultrasound pachymetry [J].
Brugin, Erica ;
Ghirlando, Alessandra ;
Gambato, Catia ;
Midena, Edoardo .
CORNEA, 2007, 26 (03) :303-307
[4]   MICROSCOPICALLY CONTROLLED EXCISION OF CONJUNCTIVAL SQUAMOUS-CELL CARCINOMA [J].
BUUNS, DR ;
TSE, DT ;
FOLBERG, R .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1994, 117 (01) :97-102
[5]   TOPICAL APPLICATION OF 5-FLUOROURACIL IN PREMALIGNANT LESIONS OF CORNEA, CONJUNCTIVA AND EYELID [J].
DEKEIZER, RJW ;
DEWOLFFROUENDAAL, D ;
VANDELFT, JL .
DOCUMENTA OPHTHALMOLOGICA, 1986, 64 (01) :31-42
[6]   THE SYNTHESIS OF 5-FLUOROPYRIMIDINES [J].
DUSCHINSKY, R ;
PLEVEN, E ;
HEIDELBERGER, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (16) :4559-4560
[7]   The microstructure of cornea verticillata in Fabry disease and amiodarone-induced keratopathy: a confocal laser-scanning microscopy study [J].
Falke, Karen ;
Buettner, Armin ;
Schittkowski, Michael ;
Stachs, Oliver ;
Kraak, Robert ;
Zhivov, Andrey ;
Rolfs, Arndt ;
Guthoff, Rudolf .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2009, 247 (04) :523-534
[8]   Mitomycin C treatment for conjunctival-corneal intraepithelial neoplasia - A multicenter experience [J].
FruchtPery, J ;
Sugar, J ;
Baum, J ;
Sutphin, JE ;
Peer, J ;
Savir, H ;
Holland, EJ ;
Meisler, DM ;
Foster, JA ;
Folberg, R ;
Rozenman, Y .
OPHTHALMOLOGY, 1997, 104 (12) :2085-2093
[9]   Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon α-2b [J].
Karp, CL ;
Moore, JK ;
Rosa, RH .
OPHTHALMOLOGY, 2001, 108 (06) :1093-1098
[10]   OCULAR SURFACE SQUAMOUS NEOPLASIA [J].
LEE, GA ;
HIRST, LW .
SURVEY OF OPHTHALMOLOGY, 1995, 39 (06) :429-450