Engineering of a Hollow-Structured Cu2-XS Nano-Homojunction Platform for Near Infrared-Triggered Infected Wound Healing and Cancer Therapy

Infection and malignant tumors are the most common diseases in people's daily life, which seriously threaten human health. Because of the frequent and extensive administration of antibiotics and chemodrugs, the prevalence of multidrug-resistant bacteria and tumor cells makes the conventional therapies less effective and even invalid. To overcome the repugnant dilemma, herein the authors devise and develop a hollow Cu2-XS nano-homojunction (nano-HJ) platform for the effective eradication of both bacteria and tumors upon tissue-penetrable near-infrared (NIR) light irradiation. Hyaluronan (HA) is covalently decorated onto the nano-homojunctions (nano-HJs) surface to enhance their biocompatibility, tumor-targeting ability, and cutaneous wound healing capability. The decorated nano-HJs exert robust NIR-activatable bactericidal modality and accelerate the cutaneous regeneration of bacteria-invaded full-thickness wounds through the synergy of photothermal/photodynamic effects, glutathione depletion, and HA assistance. After loading anticancer drug doxorubicin in the cavity of nano-HJs, the antitumor therapy efficacy is greatly strengthened both in vitro and in vivo by the collaborative photo-chemotherapy. Accordingly, this work not only highlights the great promise of the Cu2-XS nano-HJs in the treatment of bacteria-induced contagious diseases and malignant tumors but also opens up a new research direction for the biomedical application of homojunction nanoplatforms in the future.