Study of germ tube formation by Candida albicans after photodynamic antimicrobial chemotherapy (PACT)

被引：85

作者：

Munin, Egberto ^{[1
]}

Giroldo, Ligia Maria ^{[1
]}

Alves, Leandro Procopio ^{[1
]}

Costa, Maricilia Silva ^{[1
]}

机构：

[1] Univ Vale Paraiba, UNIVAP, Inst Pesquisa & Desenvolvimento, BR-12244000 Sao Jose Dos Campos, Brazil

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2007年 / 88卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

photodynamic therapy; Candida albicans; methylene blue; germ tube formation; laser;

D O I：

10.1016/j.jphotobiol.2007.04.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to the augmented number of immunocompromised patients, the infections associated to the pathogen of the genus Candida have increased dramatically in the recent years. In order to proliferate, Candida albicans can produce a germ tube formation extending from the cells. The germ tube formation is a transition state from budding to hyphal cells, and represents an essential stage for virulence. In this work we studied the effect of the photodynamic antimicrobial chemotherapy (PACT), a potential antimicrobial treatment on the germ tube formation by C. albicans. Germ tube formation was induced by goat serum after different treatments with Methylene blue (MB) and Laser (683 nm). Our results demonstrated that photodynamic therapy using MB, as a photosensitizing drug; inhibits both the growth and the germ tube formation by C. albicans. Thus, our results suggest the possibility that Methylene blue, combined with light in a specific wavelength, can be used as a promising novel antifungal agent. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：16 / 20

页数：5

共 30 条

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