A CMOS Electrochemical Impedance Spectroscopy (EIS) Biosensor Array

被引：188

作者：

Manickam, Arun ^{[1
]}

Chevalier, Aaron

McDermott, Mark ^{[1
]}

Ellington, Andrew D.

Hassibi, Arjang ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Elect & Comp Engn, Austin, TX 78712 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS | 2010年 / 4卷 / 06期

关键词：

Biosensor; DNA; electrochemical analysis; electrode; impedance spectroscopy; microarray; proteins; SELF-ASSEMBLED MONOLAYERS; LABEL-FREE; DNA; ANTIBODY; IMMOBILIZATION; MICROARRAYS; SENSORS; HEALTH; FUTURE; GOLD;

D O I：

10.1109/TBCAS.2010.2081669

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this paper, we present a fully integrated biosensor 10 x 10 array in a standard complementary metal-oxide semi-conducor process, which takes advantage of electrochemical impedance spectroscopy (EIS). We also show that this system is able to detect various biological analytes, such as DNA and proteins, in real time and without the need for molecular labels. In each pixel of this array, we implement a biocompatible Au electrode transducer and embedded sensor circuitry which takes advantage of the coherent detector to measure the impedance of the associated electrode-electrolyte interface. This chip is capable of concurrently measuring admittance values as small as 10(-8) Omega(-1) within the array with the detection dynamic range of more than 90 dB in the frequency range of 10 Hz-50 MHz.

引用

页码：379 / 390

页数：12

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