Atom-efficient transition-metal-free arylation of N,O-acetals using diarylzinc reagents through Zn/Zn cooperativity

被引：8

作者：

Borys, Andryj M. ^{[1
]}

Gil-Negrete, Jose M. ^{[1
]}

Hevia, Eva ^{[1
]}

机构：

[1] Univ Bern, Dept Chem Biochem & Pharm, Bern, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 71期

关键词：

3-COMPONENT SYNTHESIS; AMINES; SECONDARY;

D O I：

10.1039/d1cc04137a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Exploiting the cooperative action of Lewis acid Zn(C6F5)(2) with diarylzinc reagents, the efficient arylation of N,O-acetals to access diarylmethylamines is reported. Reactions take place under mild reaction conditions without the need for transtion-metal catalysis. Mechanistic investigations have revealed that Zn(C6F5)(2) not only acts as a Lewis acid activator, but also enables the regeneration of nucleophilic ZnAr2 species, allowing a limiting 50 mol% to be employed.

引用

页码：8905 / 8908

页数：4

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