The safety and effectiveness of bone marrow concentrate injection for knee and hip osteoarthritis: a Canadian cohort

被引：12

作者：

Burnham, Robert ^{[1
,2
,3
]}

Smith, Ashley ^{[2
,4
]}

Hart, David ^{[5
,6
,7
]}

机构：

[1] Cent Alberta Pain & Rehabil Inst, Lacombe, AB, Canada

[2] Vivo Cura Hlth, Calgary, AB, Canada

[3] Univ Alberta, Div Phys Med & Rehabil, Edmonton, AB, Canada

[4] Univ Calgary, Cumming Sch Med, Dept Clin Neurosci, Calgary, AB, Canada

[5] Univ Calgary, Dept Surg, Calgary, AB, Canada

[6] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada

[7] Alberta Hlth Serv, Bone & Joint Hlth Strateg Clin Network, Edmonton, AB, Canada

来源：

REGENERATIVE MEDICINE | 2021年 / 16卷 / 07期

关键词：

bone marrow concentrate; hip; knee; mesenchymal stem cell; osteoarthritis; ultrasound guided intra-articular injection;

D O I：

10.2217/rme-2021-0001

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Aim: Describe the safety and effectiveness of intra-articular bone marrow concentrate (BMC) injection to treat knee and/or hip osteoarthritis (OA) in a Canadian cohort. Materials & methods: A total of 112 patients with refractory OA received a single intra-articular injection of BMC into their knee(s) and/or hip(s). Pain, disability and quality of life were prospectively assessed prior to and 3, 6 and 12 months post-injection. Results: Outcome scores were significantly improved at all time points post-BMC injection with maximal improvement observed at 3-6 months. Improvements were unrelated to patient age, sex or radiographic OA severity. The complication rate was Interpretation: In this Canadian cohort, knee/hip OA treated with a single BMC injection resulted in significant improvements in pain, disability and quality of life and a low complication rate.

引用

页码：619 / 628

页数：10

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