The safety and effectiveness of bone marrow concentrate injection for knee and hip osteoarthritis: a Canadian cohort

被引：12
作者：
Burnham, Robert [1 ,2 ,3 ]
Smith, Ashley [2 ,4 ]
Hart, David [5 ,6 ,7 ]
机构：
[1] Cent Alberta Pain & Rehabil Inst, Lacombe, AB, Canada
[2] Vivo Cura Hlth, Calgary, AB, Canada
[3] Univ Alberta, Div Phys Med & Rehabil, Edmonton, AB, Canada
[4] Univ Calgary, Cumming Sch Med, Dept Clin Neurosci, Calgary, AB, Canada
[5] Univ Calgary, Dept Surg, Calgary, AB, Canada
[6] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada
[7] Alberta Hlth Serv, Bone & Joint Hlth Strateg Clin Network, Edmonton, AB, Canada
来源：
REGENERATIVE MEDICINE | 2021年 / 16卷 / 07期
关键词：
bone marrow concentrate; hip; knee; mesenchymal stem cell; osteoarthritis; ultrasound guided intra-articular injection;
D O I：
10.2217/rme-2021-0001
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Aim: Describe the safety and effectiveness of intra-articular bone marrow concentrate (BMC) injection to treat knee and/or hip osteoarthritis (OA) in a Canadian cohort. Materials & methods: A total of 112 patients with refractory OA received a single intra-articular injection of BMC into their knee(s) and/or hip(s). Pain, disability and quality of life were prospectively assessed prior to and 3, 6 and 12 months post-injection. Results: Outcome scores were significantly improved at all time points post-BMC injection with maximal improvement observed at 3-6 months. Improvements were unrelated to patient age, sex or radiographic OA severity. The complication rate was Interpretation: In this Canadian cohort, knee/hip OA treated with a single BMC injection resulted in significant improvements in pain, disability and quality of life and a low complication rate.
引用
收藏
页码：619 / 628
页数：10
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