The genetic basis of disease

被引：175
作者：
Jackson, Maria [1 ]
Marks, Leah [1 ]
May, Gerhard H. W. [1 ]
Wilson, Joanna B. [2 ]
机构：
[1] Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow G12 8QQ, Lanark, Scotland
[2] Univ Glasgow, Coll Med Vet & Life Sci, Sch Life Sci, Glasgow G12 8QQ, Lanark, Scotland
来源：
UNDERSTANDING BIOCHEMISTRY 4 | 2018年 / 62卷 / 05期
关键词：
D O I：
10.1042/EBC20170053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and differences in how that DNA functions (alone or in combinations), alongside the environment (which encompasses lifestyle), contribute to disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer and complex disorders, and considers how our understanding and technological advances can be applied to provision of appropriate diagnosis, management and therapy for patients.
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收藏
页码：643 / 723
页数：81
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