Mitochondrial ion channels: Gatekeepers of life and death

被引:196
作者
O'Rourke, B [1 ]
Cortassa, S [1 ]
Aon, MA [1 ]
机构
[1] Johns Hopkins Univ, Div Cardiol, Inst Mol Cardiobiol, Baltimore, MD 21218 USA
关键词
D O I
10.1152/physiol.00020.2005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Continuous generation of ATP by mitochondrial oxidative phosphorylation is essential to maintain function in mechanically active cells such as cardiomyocytes. Emerging evidence indicates that mitochondrial ion channels activated by reactive oxygen species can induce a mitochondrial "critical" state, which can scale to cause electrical and contractile dysfunction of the cardiac cell and, ultimately, the whole heart. Here we focus on how mitochondrial ion channels participate in life-and-death decisions of the cell and discuss the challenges ahead for translating recent findings into novel therapeutic applications.
引用
收藏
页码:303 / 315
页数:13
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