Androgens: Biphasic dose responses

被引：26

作者：

Calabrese, EJ ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2001年 / 31卷 / 4-5期

关键词：

testosterone; androgen; hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated;

D O I：

10.1080/20014091111794

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Testosterone was reported to affect a variety of reproductive endpoints. More notable were the effects of dihydrotestosterone on cell proliferation in the prostate cancer cell model LNCaP and Sertoli cell function. Testosterone production was also biphasically affected by prolactin that was administered to adult testicular cells in vitro.

引用

页码：517 / 522

页数：6

共 42 条

[1]

AUDI, 1984, J CLIN ENDOCRINOL ME, V58, P819

[2] CHANGES IN PITUITARY-TESTICULAR SYSTEM WITH AGE [J].

BAKER, HWG ;

BURGER, HG ;

KRETSER, DMD ;

HUDSON, B ;

OCONNOR, S ;

WANG, C ;

MIROVICS, A ;

COURT, J ;

DUNLOP, M ;

RENNIE, GC .

CLINICAL ENDOCRINOLOGY, 1976, 5 (04) :349-372

[3] EFFECT OF TESTOSTERONE THERAPY ON BONE-FORMATION IN AN OSTEOPOROTIC HYPOGONADAL MALE [J].

BARAN, DT ;

BERGFELD, MA ;

TEITELBAUM, SL ;

AVIOLI, LV .

CALCIFIED TISSUE RESEARCH, 1978, 26 (02) :103-106

[4] HORMONAL INTERACTIONS IN REGULATION OF ANDROGEN SECRETION [J].

BARTKE, A ;

HAFIEZ, AA ;

BEX, FJ ;

DALTERIO, S .

BIOLOGY OF REPRODUCTION, 1978, 18 (01) :44-54

[5] STIMULATORY EFFECTS OF ANDROGENS, ESTROGENS, PROGESTINS, AND DEXAMETHASONE ON THE GROWTH OF THE LNCAP HUMAN PROSTATE-CANCER CELLS [J].

BELANGER, C ;

VEILLEUX, R ;

LABRIE, F .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 595 :399-402

[6]

BRUCHOVSKY N, 1968, J BIOL CHEM, V243, P2012

[7] BIOLOGICAL EFFECTS OF ANDROGENS AND IDENTIFICATION OF SPECIFIC DIHYDROTESTOSTERONE-BINDING SITES IN CULTURED HUMAN-FETAL EPIPHYSEAL CHONDROCYTES [J].

CARRASCOSA, A ;

AUDI, L ;

FERRANDEZ, MA ;

BALLABRIGA, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (01) :134-140

[8] EVIDENCE OF STEROID-RECEPTORS IN HUMAN OSTEOBLAST-LIKE CELLS [J].

COLVARD, D ;

SPELSBERG, T ;

ERIKSEN, E ;

KEETING, P ;

RIGGS, BL .

CONNECTIVE TISSUE RESEARCH, 1989, 20 (1-4) :33-40

[9] IDENTIFICATION OF ANDROGEN RECEPTORS IN NORMAL HUMAN OSTEOBLAST-LIKE CELLS [J].

COLVARD, DS ;

ERIKSEN, EF ;

KEETING, PE ;

WILSON, EM ;

LUBAHN, DB ;

FRENCH, FS ;

RIGGS, BL ;

SPELSBERG, TC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (03) :854-857

[10] OSTEOPOROSIS IN HYPOGONADAL MEN - ROLE OF DECREASED PLASMA 1,25-DIHYDROXYVITAMIN-D, CALCIUM MALABSORPTION, AND LOW BONE-FORMATION [J].

FRANCIS, RM ;

PEACOCK, M ;

AARON, JE ;

SELBY, PL ;

TAYLOR, GA ;

THOMPSON, J ;

MARSHALL, DH ;

HORSMAN, A .

BONE, 1986, 7 (04) :261-268

← 1 2 3 4 5 →