Hybrid materials applied to biotechnologies:: coating of calcium phosphates for the design of implants active against bone resorption disorders

被引：36
作者：
Roussière, H
Montavon, G
Samia, LB
Janvier, P
Alonso, B
Fayon, F
Petit, M
Massiot, D
Bouler, JM
Bujoli, B
机构：
[1] CNRS, UMR 6513, Synth Organ Lab, F-44322 Nantes, France
[2] CNRS, FR 2465, F-44322 Nantes, France
[3] INSERM, Fac Chirurg Dent, EM 99 03, F-44042 Nantes, France
[4] Ecole Mines, CNRS, UMR 6457, Lab Phys Subatom & Technol Associees, F-44307 Nantes, France
[5] CNRS, CRMHT, UPR 4212, F-45071 Orleans, France
来源：
JOURNAL OF MATERIALS CHEMISTRY | 2005年 / 15卷 / 35-36期
关键词：
D O I：
10.1039/b503680a
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The reaction of a bisphosphonate bone resorption inhibitor ( Zoledronate) with calcium deficient hydroxyapatites (CDAs) was studied as a potential route to local drug delivery systems active against bone resorption disorders. A simple mathematical model of the Zoledronate - CDA interaction was designed that correctly described the adsorption of Zoledronate onto CDAs. The resulting Zoledronate-loaded materials were found to release the drug in different phosphate-containing media, with a satisfactory agreement between experimental data and the values predicted from the model.
引用
收藏
页码：3869 / 3875
页数：7
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