Lack of Compartmentalization of HIV-1 Quasispecies Between the Gut and Peripheral Blood Compartments

被引：38

作者：

Imamichi, Hiromi ^{[1
]}

DeGray, Gerald ^{[2
]}

Dewar, Robin L. ^{[2
]}

Mannon, Peter ^{[3
]}

Yao, Michael ^{[3
]}

Chairez, Cheryl ^{[1
]}

Sereti, Irini ^{[1
]}

Kovacs, Joseph A. ^{[4
]}

机构：

[1] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[2] NCI, Clin Serv Program, SAIC Frederick, Frederick, MD 21701 USA

[3] NIAID, Host Def Lab, Bethesda, MD 20892 USA

[4] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 02期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; LYMPHOID-TISSUE; T-CELLS; EXPRESSION; LYMPHOCYTES; ACTIVATION; MUCOSA;

D O I：

10.1093/infdis/jir259

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Compartmental differences in human immunodeficiency virus type 1 (HIV-1) between the gut and peripheral blood and within the gut were examined. Biopsy specimens from the colon and ileum and peripheral blood samples were collected from chronically HIV-1-infected individuals. HIV-1 envelope sequences were examined from cell-associated DNA and RNA and virion RNA. Phylogenetic analysis revealed no evidence of compartmentalization of HIV-1 between the gut and peripheral blood and within the gut (colon and ileum). HIV-1 sequences detected in the gut were transcriptionally active and were also found in peripheral blood from matching time points, providing evidence of ongoing virus production in the gut and equilibrium of HIV-1 between the gut and peripheral blood compartments.

引用

页码：309 / 314

页数：6

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